TY - JOUR AU - Martin, Emily B. AU - Williams, Angela AU - Richey, Tina AU - Wooliver, Craig AU - Stuckey, Alan AU - Foster, James S. AU - Kennel, Stephen J. AU - Wall, Jonathan S. PY - 2017 DA - 2017/12/11 TI - Evaluation of the effect of d-amino acid incorporation into amyloid-reactive peptides JO - Journal of Translational Medicine SP - 247 VL - 15 IS - 1 AB - Systemic amyloidoses comprise diseases characterized by the deposition of proteinaceous material known as amyloid. Currently, without performing multiple biopsies, there is no way to ascertain the extent of amyloid deposition in patients—a critical piece of information that informs prognosis and therapeutic strategies. We have developed pan-amyloid-targeting peptides for imaging amyloid and recently have adapted these for use as pre-targeting agents in conjunction with immunotherapy. Incorporation of d-amino acids in these peptides may enhance serum half-life, which is an important characteristic of effective peptide therapeutics. Herein, we assess the effects of partial incorporation of d-amino acids into the amyloidophilic peptide p5 on in vivo amyloid reactivity. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-017-1351-0 DO - 10.1186/s12967-017-1351-0 ID - Martin2017 ER -