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Table 6 Cox analyses of patterns identified using survival tree in the male population, Tehran Lipid and Glucose Study (1999–2014)

From: Application of survival tree analysis for exploration of potential interactions between predictors of incident chronic kidney disease: a 15-year follow-up study

Nodes Number of cases/number of events Pattern description HRs (95% CI) p-value
15 331/8 eGFR > 74 ml/min/1.73 m2, age ≤ 46 year, PAL < 600 MET, WC ≤ 100 cm, FPG ≤ 4.7 mmol/l Reference
4 110/58 eGFR ≤ 63.4 ml/min/1.73 m2, age ≤ 50 year 34.67 (16.54–72.65) < 0.001
5 192/130 eGFR ≤ 63.4 ml/min/1.73 m2, age > 50 year 70.68 (34.57–144.52) < 0.001
7 432/130 63.4 < eGFR ≤ 74 ml/min/1.73 m2, age ≤ 50 year 14.91 (7.30–30.45) < 0.001
8 365/172 63.4 < eGFR ≤ 74 ml/min/1.73 m2, age > 50 year 35.82 (17.61–72.85) < 0.001
11 368/62 70 < eGFR ≤ 74 ml/min/1.73 m2, age ≤ 46 year 7.48 (3.58–15.62) < 0.001
16 771/39 eGFR > 74 ml/min/1.73 m2, age ≤ 46 year, PAL < 600 MET, WC ≤ 100 cm, FPG > 4.7 mmol/l 2.16 (1.01–4.63) < 0.05
17 143/14 eGFR > 74 ml/min/1.73 m2, age ≤ 46 year, PAL < 600 MET, WC > 100 cm 4.67 (1.95–11.13) < 0.001
18 481/27 eGFR > 74 ml/min/1.73 m2, age ≤ 46 year, PAL ≥ 600 MET 3.02 (1.37–6.67) < 0.001
20 237/37 eGFR > 70 ml/min/1.73 m2, age > 46 year, SBP ≤ 119 mmHg 8.63 (4.02–18.55) < 0.001
22 262/75 eGFR > 70 ml/min/1.73 m2, age > 46 year, SBP > 119 mmHg, FPG ≤ 5.8 mmol/l 15.47 (7.46–32.08) < 0.001
23 103/41 eGFR > 70 ml/min/1.73 m2, age > 46 year, SBP > 119 mmHg, FPG > 5.8 mmol/l 27.26 (12.77–58.18) < 0.001
  1. Column 1 shows the number of terminal nodes of survival tree of Fig. 3 for male population. Column 2 displays the sample size and number of events in each terminal node. Column 3 represents the patterns of each terminal node. Column 4 shows the HR for each node compared to node with high survival probability as the reference node
  2. CI Confidence intervals, HRs Hazard ratio, SBP Systolic blood pressure, eGFR Estimated glomerular filtration rate, FPG Fasting plasma glucose, PAL Physical activity level, WC Waist circumference, MET Metabolic equivalent of task