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Table 6 Cox analyses of patterns identified using survival tree in the male population, Tehran Lipid and Glucose Study (1999–2014)

From: Application of survival tree analysis for exploration of potential interactions between predictors of incident chronic kidney disease: a 15-year follow-up study

Nodes

Number of cases/number of events

Pattern description

HRs (95% CI)

p-value

15

331/8

eGFR > 74 ml/min/1.73 m2, age ≤ 46 year, PAL < 600 MET, WC ≤ 100 cm, FPG ≤ 4.7 mmol/l

Reference

–

4

110/58

eGFR ≤ 63.4 ml/min/1.73 m2, age ≤ 50 year

34.67 (16.54–72.65)

< 0.001

5

192/130

eGFR ≤ 63.4 ml/min/1.73 m2, age > 50 year

70.68 (34.57–144.52)

< 0.001

7

432/130

63.4 < eGFR ≤ 74 ml/min/1.73 m2, age ≤ 50 year

14.91 (7.30–30.45)

< 0.001

8

365/172

63.4 < eGFR ≤ 74 ml/min/1.73 m2, age > 50 year

35.82 (17.61–72.85)

< 0.001

11

368/62

70 < eGFR ≤ 74 ml/min/1.73 m2, age ≤ 46 year

7.48 (3.58–15.62)

< 0.001

16

771/39

eGFR > 74 ml/min/1.73 m2, age ≤ 46 year, PAL < 600 MET, WC ≤ 100 cm, FPG > 4.7 mmol/l

2.16 (1.01–4.63)

< 0.05

17

143/14

eGFR > 74 ml/min/1.73 m2, age ≤ 46 year, PAL < 600 MET, WC > 100 cm

4.67 (1.95–11.13)

< 0.001

18

481/27

eGFR > 74 ml/min/1.73 m2, age ≤ 46 year, PAL ≥ 600 MET

3.02 (1.37–6.67)

< 0.001

20

237/37

eGFR > 70 ml/min/1.73 m2, age > 46 year, SBP ≤ 119 mmHg

8.63 (4.02–18.55)

< 0.001

22

262/75

eGFR > 70 ml/min/1.73 m2, age > 46 year, SBP > 119 mmHg, FPG ≤ 5.8 mmol/l

15.47 (7.46–32.08)

< 0.001

23

103/41

eGFR > 70 ml/min/1.73 m2, age > 46 year, SBP > 119 mmHg, FPG > 5.8 mmol/l

27.26 (12.77–58.18)

< 0.001

  1. Column 1 shows the number of terminal nodes of survival tree of Fig. 3 for male population. Column 2 displays the sample size and number of events in each terminal node. Column 3 represents the patterns of each terminal node. Column 4 shows the HR for each node compared to node with high survival probability as the reference node
  2. CI Confidence intervals, HRs Hazard ratio, SBP Systolic blood pressure, eGFR Estimated glomerular filtration rate, FPG Fasting plasma glucose, PAL Physical activity level, WC Waist circumference, MET Metabolic equivalent of task