|
Variables
|
HRs
|
95% Confidence interval
|
p-value
|
|---|
|
Men
|
|
Age (years)
|
1.04
|
1.03–1.05
|
< 0.001
|
|
eGFR (ml/min/1.73 m2)
|
0.90
|
0.89–0.91
|
< 0.001
|
|
FPG (mmol/l)
|
1.10
|
1.05–1.16
|
< 0.001
|
|
DBP (mmHg)
|
1.02
|
1.01–1.03
|
< 0.001
|
|
TC (mmol/l)
|
0.89
|
0.83–0.96
|
0.0025
|
|
Waist circumference (cm)
|
0.98
|
0.97–0.99
|
0.016
|
|
Hip circumference (cm)
|
1.02
|
1.00–1.03
|
0.075
|
|
Heart rate (beats/min)
|
0.99
|
0.99–1.00
|
0.093
|
|
Education
|
|
Level 1 (illiterate)
|
Reference
| | |
|
Level 2 (< 9 years)
|
1.18
|
0.83–1.67
|
0.34
|
|
Level 3 (9–12 years)
|
1.24
|
0.87–1.78
|
0.23
|
|
Level 4 (> 12 years)
|
1.56
|
1.06–2.28
|
0.021
|
|
Marital status
|
|
Married
|
Reference
| | |
|
Single
|
1.06
|
0.77–1.47
|
0.70
|
|
Divorced/widowed
|
2.04
|
1.09–3.84
|
0.025
|
|
FH–CVD in female relatives
|
|
No
|
Reference
| | |
|
Yes
|
1.25
|
0.97–1.62
|
0.080
|
|
PAL
|
|
Inactivea
|
Reference
| | |
|
Active
|
1.21
|
1.03–1.42
|
0.016
|
|
Smoking
|
|
Never
|
Reference
| | |
|
Past
|
1.06
|
0.87–1.30
|
0.51
|
|
Current
|
1.24
|
1.03–1.48
|
0.017
|
|
Use of blood glucose lowering drugs
|
|
No
|
Reference
| | |
|
Yes
|
1.59
|
1.08–2.35
|
0.017
|
|
Use of aspirin
|
|
No
|
Reference
| | |
|
Yes
|
0.84
|
0.67–1.04
|
0.116
|
|
Women
|
|
Age (years)
|
1.02
|
1.02–1.03
|
< 0.001
|
|
eGFR (mL/min/10.73 m2)
|
0.91
|
0.91–0.92
|
< 0.001
|
|
FPG (mmol/L)
|
1.05
|
1.02–1.08
|
< 0.001
|
|
Heart rate (beats/min)
|
0.99
|
0.98–0.99
|
< 0.001
|
|
Waist circumference (cm)
|
0.99
|
0.98–0.99
|
0.002
|
|
SBP (mmHg)
|
1.01
|
1.00–1.01
|
0.028
|
|
Wrist circumference (cm)
|
1.05
|
1.00–1.01
|
0.119
|
|
FHD in first-degree relatives
|
|
No
|
Reference
| | |
|
Yes
|
0.90
|
0.79–1.01
|
0.08
|
|
Prevalence CVD
|
|
No
|
Reference
| | |
|
Yes
|
1.35
|
0.99–1.82
|
0.048
|
- The Stepwise Cox PH regression model using AIC as model selection approach was used to identify significant predictors of incident CKD by calculating multivariable hazard ratios (HRs) with 95% CI
-
TLGS Tehran Lipid and Glucose Study, PH proportional hazard, AIC Akaike information criteria, TLGS Tehran Lipid and Glucose Study, FPG fasting plasma glucose, TC total cholesterol, eGFR estimated glomerular filtration rate, SBP systolic blood pressure, DBP diastolic blood pressure, FH-CVD family history of premature cardiovascular disease, FHD family history of diabetes mellitus, PAL physical activity level, CVD cardiovascular disease
-
aDoing exercise or labor less than three times a week or performing activities achieving < 600 metabolic equivalent of task (MET)
