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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Identification of coexistence of BRAF V600E mutation and EZH2 gain specifically in melanoma as a promising target for combination therapy

Fig. 6

Proliferation index of tumor cells from PDX models after monotherapy and combination therapy. On day 14 of treatments, the tumor nodules were excised and examined by H&E staining and immuohistochemical staining (for Ki-67, P-AKT and P-ERK). The sections were evaluated under microscope, and typical staining was photographed (a) and the Ki-67+, P-AKT+ and P-ERK+ cells under five random fields were counted. b Graphs of the analysis were shown. The results of were presented as mean ± SD of three sections. The statistical significance was evaluated by One-way ANOVA. (*P < 0.05; **P < 0.01; ***P < 0.001). c TGI of three therapeutic regimens on two types of PDX models were shown

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