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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling

Fig. 3

Loss of PTHLH significantly suppressed cell proliferation. ac PTHLH deletion suppresses tumor growth. Five nude mice were injected subcutaneously with 1 × 107 cells/mouse for each of the indicated stable cell lines. The results are presented as isolated tumors (a), tumor sizes (b), and tumor weights (c). d H&E staining of xenograft tumor from nude mice injected with shCtrl or shPTHLHx cells (scale bar, 20 μm). e Representative images of Ki67, CyclinD1, and CDK4 protein expression in xenograft tumors from nude mice as assessed by immunohistochemistry (DAB staining, scale bar, 50 μm)

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