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Table 4 We conducted case study of hepatocellular carcinoma in the second way, in which we removed all the hepatocellular carcinoma related miRNAs information to simulate a new disease without any known associations

From: MKRMDA: multiple kernel learning-based Kronecker regularized least squares for MiRNA–disease association prediction

miRNA

Evidence

miRNA

Evidence

hsa-mir-21

HMDDv2

hsa-mir-571

Unconfirmed

hsa-mir-122

dbdemc; HMDDv2

hsa-mir-133b

HMDDv2

hsa-mir-375

HMDDv2

hsa-mir-34a

dbdemc; HMDDv2

hsa-mir-145

dbdemc; HMDDv2

hsa-let-7b

HMDDv2

hsa-mir-200c

HMDDv2

hsa-mir-138

HMDDv2

hsa-mir-200b

HMDDv2

hsa-mir-100

dbdemc; HMDDv2

hsa-mir-200a

dbdemc; HMDDv2

hsa-mir-148a

dbdemc; HMDDv2

hsa-mir-451a

HMDDv2

hsa-mir-26b

dbDEMC

hsa-mir-124

HMDDv2

hsa-mir-214

dbdemc; HMDDv2

hsa-mir-486

HMDDv2

hsa-mir-199a

dbdemc; HMDDv2

hsa-mir-210

dbdemc; HMDDv2

hsa-mir-625

Unconfirmed

hsa-mir-16

dbdemc; HMDDv2

hsa-mir-370

HMDDv2

hsa-mir-10b

HMDDv2

hsa-mir-23a

dbdemc; HMDDv2

hsa-mir-629

HMDDv2

hsa-mir-708

Unconfirmed

hsa-mir-126

dbdemc; HMDDv2

hsa-mir-499a

HMDDv2

hsa-mir-196a

HMDDv2

hsa-mir-184

Unconfirmed

hsa-mir-31

HMDDv2

hsa-mir-378a

HMDDv2

hsa-mir-425

HMDDv2

hsa-mir-141

HMDDv2

hsa-mir-143

dbdemc

hsa-mir-548d

Unconfirmed

hsa-mir-182

HMDDv2

hsa-mir-25

dbdemc; HMDDv2

hsa-let-7i

dbdemc; HMDDv2

hsa-mir-34c

HMDDv2

hsa-mir-222

dbdemc; HMDDv2

hsa-mir-1290

HMDDv2

hsa-mir-26a

dbdemc; HMDDv2

hsa-mir-494

Unconfirmed

hsa-mir-155

dbdemc; HMDDv2

hsa-mir-320b

HMDDv2

hsa-let-7a

dbdemc; HMDDv2

hsa-mir-105

HMDDv2

  1. Then we verified the prediction results based on HMDD v2.0 database, miR2Disease, and dbDEMC database. As a result, among the top 10 and 50 potential miRNAs, 10 and 44 were confirmed