Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients

Table 8 Combined effects of rs7278, rs3734703 and rs1042919 genotypes on chemotherapy response in AML patients

Composite score^a	N	CR (%)	P	P ^b	OR (95% CI)^b
0	32	68.8			1.00 (reference)
1	77	79.2	0.246	0.270	1.767 (0.642–4.865)
2	79	94.9	0.001	0.001	8.604 (2.318–31.93)
3	18	100	0.998	0.998	–
1 + 2 + 3	174	85.4	0.005	0.008	3.624 (1.398–9.395)

^aCombined genotype score model was created by compiling the genotyped data of SNPs rs7278, rs3734703 and rs1042919. Score 1 indicated favorable genotypes (i.e., rs7278 TT/TC genotype, rs3734703 CC/AA genotype, or rs1042919 TT genotype) and a score of 0 indicated unfavorable genotypes (i.e., rs7278 CC genotype, rs734693 CA genotype, or rs1042919 AA/AT genotype). After adding up these scores, four composite score groups were generated: composite score 0, 1, 2 and 3
^bAdjusted for age, risk stratifications and platelets

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