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Table 8 Combined effects of rs7278, rs3734703 and rs1042919 genotypes on chemotherapy response in AML patients

From: Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients

Composite scorea N CR (%) P P b OR (95% CI)b
0 32 68.8    1.00 (reference)
1 77 79.2 0.246 0.270 1.767 (0.642–4.865)
2 79 94.9 0.001 0.001 8.604 (2.318–31.93)
3 18 100 0.998 0.998
1 + 2 + 3 174 85.4 0.005 0.008 3.624 (1.398–9.395)
  1. aCombined genotype score model was created by compiling the genotyped data of SNPs rs7278, rs3734703 and rs1042919. Score 1 indicated favorable genotypes (i.e., rs7278 TT/TC genotype, rs3734703 CC/AA genotype, or rs1042919 TT genotype) and a score of 0 indicated unfavorable genotypes (i.e., rs7278 CC genotype, rs734693 CA genotype, or rs1042919 AA/AT genotype). After adding up these scores, four composite score groups were generated: composite score 0, 1, 2 and 3
  2. bAdjusted for age, risk stratifications and platelets