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Table 6 Significant effects of poly-miRTS on OS of AML patients by univariate and multivariate Cox regression analysis

From: Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients

Genotype

Mean ± SE (day)

P

RR (95% CI)

Pa

RR (95% CI)a

rs10786736

 GG

1134 ± 115

 

1.00 (reference)

 

1.00 (reference)

 CC

1367 ± 149

0.236

0.414 (0.096–1.780)

0.253

0.426 (0.099–1.836)

 CG

1550 ± 95

0.022

0.404 (0.186–0.876)

0.016

0.386 (0.177–0.839)

 CC+CGb

1560 ± 85

0.015

0.406 (0.196–0.841)

0.012

0.392 (0.189–0.815)

 GG+CCc

1192 ± 107

0.045

2.178 (1.018–4.660)

0.033

2.297 (1.070–4.933)

rs3734703

 CC

1571 ± 83

 

1.00 (reference)

 

1.00 (reference)

 AA

801 ± 146

0.001

5.121 (1.985–13.214)

0.000

5.877 (2.244–15.39)

 CA

1290 ± 127

0.056

2.231 (0.981–5.073)

0.057

2.219 (0.975–5.050)

 AA+CAb

1100 ± 133

0.006

2.842 (1.350–5.980)

0.005

2.902 (1.377–6.117)

rs8139

 TT

1440 ± 137

 

1.00 (reference)

 

1.00 (reference)

 CC

1039 ± 166

0.042

2.538 (1.033–6.236)

0.060

2.370 (0.963–5.831)

 CT

1526 ± 93

0.391

0.671 (0.270–1.669)

0.204

0.547 (0.215–1.388)

 CC/CT

 

0.002

3.782 (1.662–8.607)

0.001

4.334 (1.885–9.964)

 TT+CTd

1510 ± 78

0.001

3.259 (1.574–6.746)

0.001

3.475 (1.674–7.213)

  1. Italic values indicate statistical significance
  2. aAdjusted for risk stratifications, high risk vs. low + intermediate risk
  3. bThe dominant model
  4. cThe overdominance model
  5. dThe recessive model