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Table 6 Significant effects of poly-miRTS on OS of AML patients by univariate and multivariate Cox regression analysis

From: Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients

Genotype Mean ± SE (day) P RR (95% CI) Pa RR (95% CI)a
rs10786736
 GG 1134 ± 115   1.00 (reference)   1.00 (reference)
 CC 1367 ± 149 0.236 0.414 (0.096–1.780) 0.253 0.426 (0.099–1.836)
 CG 1550 ± 95 0.022 0.404 (0.186–0.876) 0.016 0.386 (0.177–0.839)
 CC+CGb 1560 ± 85 0.015 0.406 (0.196–0.841) 0.012 0.392 (0.189–0.815)
 GG+CCc 1192 ± 107 0.045 2.178 (1.018–4.660) 0.033 2.297 (1.070–4.933)
rs3734703
 CC 1571 ± 83   1.00 (reference)   1.00 (reference)
 AA 801 ± 146 0.001 5.121 (1.985–13.214) 0.000 5.877 (2.244–15.39)
 CA 1290 ± 127 0.056 2.231 (0.981–5.073) 0.057 2.219 (0.975–5.050)
 AA+CAb 1100 ± 133 0.006 2.842 (1.350–5.980) 0.005 2.902 (1.377–6.117)
rs8139
 TT 1440 ± 137   1.00 (reference)   1.00 (reference)
 CC 1039 ± 166 0.042 2.538 (1.033–6.236) 0.060 2.370 (0.963–5.831)
 CT 1526 ± 93 0.391 0.671 (0.270–1.669) 0.204 0.547 (0.215–1.388)
 CC/CT   0.002 3.782 (1.662–8.607) 0.001 4.334 (1.885–9.964)
 TT+CTd 1510 ± 78 0.001 3.259 (1.574–6.746) 0.001 3.475 (1.674–7.213)
  1. Italic values indicate statistical significance
  2. aAdjusted for risk stratifications, high risk vs. low + intermediate risk
  3. bThe dominant model
  4. cThe overdominance model
  5. dThe recessive model
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Journal of Translational Medicine

ISSN: 1479-5876

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