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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: The macrophage C-type lectin receptor CLEC5A (MDL-1) expression is associated with early plaque progression and promotes macrophage survival

Fig. 4

MDL-1 expression is regulated by pathophysiological agents implicated in atherosclerotic progression and regression in vitro. Western blot analyses of MDL-1 protein level in C57BL/6 mice peritoneal macrophages treated with a 50 μg/mL ox-LDL for the indicated times or b CoCl2 at the concentrations indicated for 24 h. Band densitometry are quantified. c Macrophages were stimulated with 50 μg/mL ox-LDL with or without pretreatment with 100 μmol/L HIF-1α inhibitor. d Macrophages were stimulated with 200 μmol/L CoCl2 with or without pretreatment with 100 μmol/L HIF-1α inhibitor. Band densitometry quantification are shown. e Macrophages were treated with 50 μg/mL ox-LDL with or without pretreatment with 10 μg/mL HDL. Images are representative of three independent experiments. Values are expressed as mean ± SEM. *p < 0.05; # p < 0.01

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