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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: The macrophage C-type lectin receptor CLEC5A (MDL-1) expression is associated with early plaque progression and promotes macrophage survival

Fig. 3

MDL-1 expression is downregulated in regressive plaques and has a proinflammatory phenotype in the lesion. a Immunofluorescent staining of MDL-1 (green) and MOMA-2 (red) in aortic sinus plaques in a progressive (ldlr−/− mice fed a 8-week HFD) or regressive (ldlr−/− mice fed a 8-week HFD and then switched to 4-week chow diet) environment. b Immunofluorescent staining of iNOS (M1 subtype macrophage marker, red) or Arg-1 (M2 subtype macrophage marker, red) in aortic sinus plaques both in progressive and regressive context. c Quantification of MDL-1 positive macrophages in a. d Real-time PCR analysis of MDL-1 mRNA in bone marrow-derived macrophages (BMDMs) polarized toward M1, M2, or unpolarized (M0). e Western-blot analysis of aortic lysates from apoE−/− mice fed a 8-week HFD or chow diet. All images are representative of at least three mice per group. Values are expressed as mean ± SEM. *p < 0.05 compared with baseline group mice or unpolarized BMDMs

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