Fig. 2

The serum total and LDL cholesterol levels were significantly lowered in LDLr−/− mice when switching to a chow diet. LDLr−/− mice fed a 8-week HFD were either sacrificed for baseline or switched to a chow diet for another 4 weeks. Total cholesterol and LDL/VLDL cholesterol concentration were decreased and HDL cholesterol was elevated in switching group compared with baseline group mice (n = 4–5 mice/group). *p < 0.05 compared with baseline group mice. LDLr low-density lipoprotein receptor, HFD high-fat diet, LDL/VLDL low-density lipoprotein/very low-density lipoprotein