Skip to main content

Table 2 Univariate and multivariate analysis of recurrence (HR) of some histopathological features of patients with nodular melanoma (NM) and superficial spreading melanomas (SSMs)

From: Clinicopathological predictors of recurrence in nodular and superficial spreading cutaneous melanoma: a multivariate analysis of 214 cases

  Recurrence Univariate Multivariatec
Yes (N. 53) No (N. 161) HR (95% CI)a HR (95% CI)a
Diagnosis
 SSMs 14 (26.4) 104 (64.6) 1b 1b
 NM 39 (73.6) 57 (35.4) 4.09 (2.22–7.53) 1.62 (0.77–3.39)
 χ2 1: p value    p < 0.0001 p = 0.2016
Thickness (mm)
 ≤ 1 7 (13.2) 74 (46.0) 1b 1b
 1.01–2.00 7 (13.2) 39 (24.2) 2.07 (0.72–5.89) 1.55 (0.51–4.71)
 2.01–4.00 28 (52.8) 38 (23.6) 5.85 (2.55–13.41) 2.42 (0.89–6.54)
 > 4.00 11 (20.8) 10 (6.2) 7.45 (2.89–19.22) 3.13 (0.95–10.28)
 χ2 1 trend: p value    p < 0.0001 p = 0.0456
Ulceration
 Absent 29 (54.7) 113 (70.2) 1b 1b
 Present 24 (45.3) 37 (23.0) 2.10 (1.22–3.61) 0.74 (0.40–1.39)
 Unknown 11 (6.8)   
 χ2 1: p value    p = 0.0073 p = 0.3513
Regression
 Absent 37 (69.8) 95 (59.0) 12  
 Present 16 (30.2) 54 (33.5) 0.81 (0.45–1.45)  
 Unknown 12 (7.5)   
 χ2 1: p value    p = 0.4687  
Mitoses (n/mm2)
 ≤ 2 13 (24.5) 104 (64.6) 1b 1b
 > 2 37 (69.8) 47 (29.2) 4.75 (2.52–8.94) 2.34 (1.11–4.97)
 Unknown 3 (5.7) 10 (6.2)   
 χ2 1: p value    p < 0.0001 p = 0.0263
TILd
 Absent 21 (39.6) 42 (26.1) 1b  
 Brisk 9 (17.0) 32 (19.9) 0.62 (0.29–1.36)  
 Non-Brisk 22 (41.5) 72 (44.7) 0.64 (0.35–1.16)  
 Unknown 1 (1.9) 15 (9.3)   
 χ2 1 trend: p value    p = 0.1527  
Lymph nodes sentinel
 No suggest 15 (28.3) 81 (50.3) 1b 1b
 Yes-negative 16 (30.2) 66 (41.0) 1.14 (0.56–2.31) 0.77 (0.35–1.69)
 Yes-positive 22 (41.5) 14 (8.7) 5.24 (2.71–10.13) 2.60 (1.19–5.68)
 χ2 1 trend: p value    p < 0.0001 p = 0.0073
  1. aHazard ratio and 95% confidence interval (CI)
  2. bReference category
  3. cModel including all significant terms in the univariate analysis
  4. dTumor infiltrating lymphocytes