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Table 1 Univariate and multivariate analysis (OR) of some histopathological features of nodular melanoma (NM) versus superficial spreading melanomas (SSMs)

From: Clinicopathological predictors of recurrence in nodular and superficial spreading cutaneous melanoma: a multivariate analysis of 214 cases

  NM
(N. 96)
SSMs
(N. 118)
Univariate
OR (95% CI)a
Multivariatec
OR (95% CI)a
Thickness (mm)
 ≤ 1.00 9 (9.4) 72 (61.0) 1b 1b
 1.01–2.00 24 (25.0) 22 (18.6) 8.73 (3.54–21.52) 7.22 (2.73–19.05)
 2.01–4.00 44 (45.8) 22 (16.6) 16.00 (6.76–37.87) 7.04 (2.54–19.56)
 > 4.00 19 (19.8) 2 (1.7) 76.00 (15.14–381.51) 51.78 (5.65–474.86)
 χ2 1 trend: p value    p < 0.0001 p < 0.0001
Ulceration
 Absent 46 (47.9) 96 (81.4) 1b 1b
 Present 43 (44.8) 18 (15.2) 4.98 (2.59–9.57) 1.56 (0.67–3.62)
 Unknown 7 (7.3) 4 (3.4)   
 χ2 1: p value    p < 0.0001 p = 0.3066
Regression
 Absent 65 (67.7) 67 (56.8) 1b 1b
 Present 24 (25.0) 46 (39.0) 0.54 (0.30–0.98) 0.55 (0.25–1.22)
 Unknown 7 (7.3) 5 (4.2)   
 χ2 1: p value    p = 0.0428 p = 0.1393
Mitoses (n/mm2)
 ≤ 2 31 (32.3) 86 (72.9) 1b 1b
 3–5 24 (25.0) 14 (11.9) 4.76 (2.19–10.34) 2.62 (1.01–6.83)
 > 5 35 (36.5) 11 (9.3) 8.83 (4.00–19.49) 4.87 (1.77–13.40)
 Unknown 6 (6.2) 7 (5.9)   
 χ2 1 trend: p value    p < 0.0001 p = 0.0015
TILd
 Absent 29 (30.2) 34 (28.8) 1b  
 Brisk 14 (14.6) 27 (22.9) 0.61 (0.27–1.37)  
 Non-Brisk 46 (47.9) 48 (40.7) 1.12 (0.59–2.13)  
 Unknown 7 (7.3) 9 (7.6)   
 χ2 1 trend: p value    p = 0.6174  
  1. aOdds Ratio and 95% confidence interval (CI)
  2. bReference category
  3. cModel including all significant terms in the univariate analysis
  4. dTumor infiltrating lymphocytes