Skip to main content

Table 1 Modified weight factors (in percent) for the items of the translatability score in the different disease areas

From: Translatability score revisited: differentiation for distinct disease areas

  Original = cardio-vascular Oncology Psychiatric Anti-viral Anti-bacterial/fungal Monogenetic orphans
Aspect
Starting evidence
  In vitro data including animal genetics 2 2 1 9 3 2
  In vivo data including animal genetics 3 1 1 1 5 2
  Animal disease models 3 5 1 1 5 2
  Data from multiple species 3 1 1 1 1 2
Human evidence
  Genetics 5 5 4 4 4 20
  Model compounds 13 10 26 12 12 2
  Clinical trials 13 11 26 12 12 10
Biomarkers for efficacy and safety prediction
  Biomarker grading 24 28 10 23 22 23
  Biomarker development 13 17 5 12 11 12
Proof-of-mechanism, proof-of-principle and proof of concept testing
  Biomarker strategy 5 5 7 5 5 5
  Surrogate or endpoint strategy 8 2 12 7 7 7
Personalized medicine aspects
  Disease sub-classification and responder concentration 3 7 2 9 9 9
  Pharmacogenetics 5 6 4 4 4 4
  Sum 100 100 100 100 100 100
  1. Deviations from the original = cardiovascular score by more than two points are in italic