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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Efficient generation of P53 biallelic knockout Diannan miniature pigs via TALENs and somatic cell nuclear transfer

Fig. 4

Identification of transgenic piglets. a Obtained partly P53 KO piglets. b The sequences of the P53 mutation in cloned piglets. The WT sequence is shown above. Deletions (denoted with “Δ” and the number of base pairs) are identified. c The relative expression levels of P53 mRNA in the different tissues from P53 KO and WT piglets. The relative expression levels of P53 mRNA in brain, muscle, kidney, heart, liver and kidney tissues of P53 KO and WT piglets were measured using q-PCR. Expression of the GAPDH gene was used to normalize the values of P53. * p < 0.05 and ** p < 0.01 denote significant differences in P53 KO piglets compared to WT piglets

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