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Table 1 Skin-resident cells interacting with Treg cells

From: Therapeutic application of T regulatory cells in composite tissue allotransplantation

Cell type Action References
Langerhans cells Activate and proliferate Treg cells in resting state; limit activation of Treg cells in presence of pathogen [116]
Induce Treg cells favoring flora tolerance with limited antigens presentation [117]
Induce Treg cells by secretion of IL-10 and TGF-β [118]
Memory Treg cells Localize to hair follicles
Non-migratory and non-responsive in normal skin
Proliferate and produce IL-17 in inflamed skin
[119]
Are activated, proliferated and differentiated into potent suppressor
Attenuate autoimmune reactions in tissues upon repeated responses to antigens
[120]
Macrophages Promote expression of the chemokine CCL22
Induce migration and activation of Treg cells
[121]
Express M2-like TIM-4hiCD169+
Act immunoregulatory function and promote engraftment of cardiac allografts
[122]
Mast cells Act as intermediate at Treg cells dependent allograft tolerance via IL-9 [123]
Counteract Treg cell function through IL-6 and OX40/OX40L axis toward Th17 cell differentiation [124]
Dermal dendritic cells Are capable of antigen capture and presentation to CD4+ T cells and Treg cells generation [125]
Dermal regulatory cells Induce Treg cells through PD-1 engagement with expression of ABCB5+ molecules [126]
Dermal fibroblasts Induce proliferation of natural Treg cells with IL-15 [127]
Dermal stromal cells Express CD90+ and induce Tregs cells [128]
  1. CCL chemokine ligand, TIM T cell immunoglobulin mucin, ABCB5 ATP binding cassette subfamily B member 5