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Table 5 Sensitivity, specificity and accuracy based on quantitative FCIA and MAIPA assay

From: Flow cytometric immunobead assay for quantitative detection of platelet autoantibodies in immune thrombocytopenia patients

Autoantibody category

Case (n)

Sensitivity (%)

Specificity (%)

Accuracy (%)

Quantitative FCIA

MAIPA

Quantitative FCIA

MAIPA

Quantitative FCIA

MAIPA

Anti-GPIX (%, n/n)

114

43.90 (18/41)†

24.39 (10/41)

97.26 (71/73)

97.26 (71/73)

78.07 (89/114)

71.05 (81/114)

Anti-GPIb (%, n/n)

114

39.02 (16/41)†

19.51 (8/41)

93.15 (68/73)

94.52 (69/73)

73.68 (84/114)

67.54 (77/114)

Anti-GPIIIa (%, n/n)

114

46.34 (19/41)†

26.83 (11/41)

97.26 (71/73)

91.78 (67/73)

78.95 (90/114)

68.42 (78/114)

Anti-GPIIb (%, n/n)

114

51.22 (21/41)†

31.71 (13/41)

95.89 (70/73)

94.52 (69/73)

78.82 (91/114)

71.93 (82/114)

Anti-P-selectin (%, n/n)

114

43.90 (18/41)*

21.95 (9/41)

98.63 (72/73)

93.15 (68/73)

78.95 (90/114)

67.54 (77/114)

5 antibody combined (%, n/n)

114

68.29 (28/41)*

41.46 (17/41)

84.93 (62/73)

90.41 (66/73)

78.95 (90/114)

72.81 (83/114)

  1. FCIA flow cytometric immunobead assay, MAIPA monoclonal antibody immobilization of platelet antigen assay
  2. * p < 0.05; † p < 0.1 quantitative FCIA vs. MAIPA of the same group