Skip to main content

Table 5 Sensitivity, specificity and accuracy based on quantitative FCIA and MAIPA assay

From: Flow cytometric immunobead assay for quantitative detection of platelet autoantibodies in immune thrombocytopenia patients

Autoantibody category Case (n) Sensitivity (%) Specificity (%) Accuracy (%)
Quantitative FCIA MAIPA Quantitative FCIA MAIPA Quantitative FCIA MAIPA
Anti-GPIX (%, n/n) 114 43.90 (18/41) 24.39 (10/41) 97.26 (71/73) 97.26 (71/73) 78.07 (89/114) 71.05 (81/114)
Anti-GPIb (%, n/n) 114 39.02 (16/41) 19.51 (8/41) 93.15 (68/73) 94.52 (69/73) 73.68 (84/114) 67.54 (77/114)
Anti-GPIIIa (%, n/n) 114 46.34 (19/41) 26.83 (11/41) 97.26 (71/73) 91.78 (67/73) 78.95 (90/114) 68.42 (78/114)
Anti-GPIIb (%, n/n) 114 51.22 (21/41) 31.71 (13/41) 95.89 (70/73) 94.52 (69/73) 78.82 (91/114) 71.93 (82/114)
Anti-P-selectin (%, n/n) 114 43.90 (18/41)* 21.95 (9/41) 98.63 (72/73) 93.15 (68/73) 78.95 (90/114) 67.54 (77/114)
5 antibody combined (%, n/n) 114 68.29 (28/41)* 41.46 (17/41) 84.93 (62/73) 90.41 (66/73) 78.95 (90/114) 72.81 (83/114)
  1. FCIA flow cytometric immunobead assay, MAIPA monoclonal antibody immobilization of platelet antigen assay
  2. * p < 0.05;  p < 0.1 quantitative FCIA vs. MAIPA of the same group