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Table 4 Sensitivity, specificity and accuracy based on quantitative and qualitative FCIA assay

From: Flow cytometric immunobead assay for quantitative detection of platelet autoantibodies in immune thrombocytopenia patients

Autoantibody category

Case (n)

Sensitivity (%)

Specificity (%)

Accuracy (%)

Quantitative FCIA

Qualitative FCIA

Quantitative FCIA

Qualitative FCIA

Quantitative FCIA

Qualitative FCIA

Anti-GPIX (%, n/n)

534

31.84 (64/201)

31.34 (63/201)

91.29 (304/333)

91.29 (304/333)

68.91 (368/534)

68.73 (367/534)

Anti-GPIb (%, n/n)

534

32.84 (66/201)

32.34 (65/201)

96.40 (321/333)

96.40 (321/333)

72.47 (387/534)

72.28 (386/534)

Anti-GPIIIa (%, n/n)

534

32.84 (66/201)

27.86 (56/201)

95.20 (317/333)

97.30 (324/333)

71.72(383/534)

71.16 (380/534)

Anti-GPIIb (%, n/n)

534

30.35 (61/201)

25.87 (52/201)

95.80 (319/333)

97.30 (324/333)

71.16 (380/534)

70.41 (376/534)

Anti-P-selectin (%, n/n)

534

40.30 (81/201)

39.80 (80/201)

95.80 (319/333)

96.10 (320/333)

74.91 (400/534)

74.91 (400/534)

5 antibody combined (%, n/n)

534

73.13 (147/201)

73.13 (147/201)

81.98 (273/333)

82.88 (276/333)

78.65 (420/534)

79.21 (423/534)

  1. FCIA flow cytometric immunobead assay