|
Characteristics
|
Test set 1
|
Test set 2
|
Pilot set
|
|---|
|
ITP (n = 201)
|
Non-ITP (n = 126)
|
HC (n = 207)
|
ITP (n = 41)
|
Non-ITP (n = 37)
|
HC (n = 36)
|
ITP (n = 8)
|
|---|
|
Disease subtype (n)
|
Newly-diagnosed (63)
|
Persistent (60)
|
Chronic (78)
|
NA
|
NA
|
NA
|
NA
|
NA
|
Newly-diagnosed (8)
|
|
Gender (female/male, n)
|
45/18
|
38/22
|
48/30
|
56/70
|
76/131
|
24/17
|
11/26
|
13/23
|
5/3
|
|
Age (median, range, years)
|
53 (18, 86)
|
53 (9, 86)
|
54 (13, 83)
|
44 (13, 88)
|
48 (24, 91)
|
33 (5, 68)
|
42 (9, 64)
|
30 (21, 50)
|
38.5 (9, 69)
|
|
Platelet count (× 109/L)a
|
29.0 ± 16.9
|
41.0 ± 20.0
|
42.4 ± 20.3
|
41.5 ± 21.8
|
216.1 ± 56.8
|
38.2 ± 32.3
|
42.2 ± 31.0
|
211.4 ± 32.4
|
17.8 ± 9.9
|
|
Treatment (n, %)b
|
NA
|
58 (96.7)
|
78 (100)
|
NA
|
NA
|
27 (65.9)
|
NA
|
NA
|
NA
|
|
Steroids
|
NA
|
51 (85.0)
|
75 (96.2)
|
NA
|
NA
|
27 (65.9)
|
NA
|
NA
|
NA
|
|
Immunosuppressants
|
NA
|
15 (25.0)
|
27 (34.6)
|
NA
|
NA
|
10 (24.4)
|
NA
|
NA
|
NA
|
|
Splenectomy
|
NA
|
0 (0)
|
3 (3.8)
|
NA
|
NA
|
0 (0)
|
NA
|
NA
|
NA
|
|
Others
|
NA
|
10 (16.7)
|
23 (29.5)
|
NA
|
NA
|
5 (12.2)
|
NA
|
NA
|
NA
|
- Data are presented as mean ± SD, or percentage in parenthesis
- Steroids included dexathemethasone, prednisone or methylprednisolone; immunosuppressants included Cyclosporine A (CSA), Azathioprine (Aza) or Vindesine (VDS); others included Intravenous Immunoglobulin (IVIg), thrombopoietin (TPO) and Rituximab
-
HC healthy controls, NA not applicable or not available
-
a Platelet count at first visit
-
bAll the included patients did not receive any medical treatment for at least 1 month before sampling
