Fig. 1
From: A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma
Pharmacophore model for p32. a 3D structure of the peptide-SIVSSSRGQVRRS from the p32-binding part of protein C1q. This structure is extracted from the known PDB structure of C1q. b 3D structure of LyP-1 cyclic peptide (CGNKRTRGC) modeled with the program InsightII (Accelrys, San Diego). c Superposition of above mentioned tertiary structures. d Assignment of six-feature pharmacophore centers. Both peptides have superimposable main features: 3 Donor|Cationic centers (violet: F1, F2, and F3), 2 Hydrophobic centers (green: F5 and F6), and 1 Acceptor|Anionic center (cyan: F4)