Table 3 Immunoscore and Immunoprofiling differences
Immunoscore | Immunoprofiling | |
|---|---|---|
Prognostic/predictive (?) | Prognostic/predictive (?) | |
Number of Immunomarkers | 2–4 | 1-several |
Immunoscore markers | CD3/CD8 | Immune gene signatures |
Immunoscore-like markers | CD3/CD8/CD20/FoxP3 | Multiplex assays |
CD3/CD8/CD45RO | CD137, Galectin1, LAG-3, OX40 PD-L1, TIM3 ect. | |
CD3/CD8/CD68 | ||
CD3/CD8/CD20 | ||
CD3/GZMB | ||
CD8/FoxP3 | ||
CD8/IL17 | ||
(others) | ||
Possible applications | • Staging in colorectal cancer (already tested) | • Prognostic assay |
• Staging in melanoma, breast cancer, Ovarian cancer, NSCLC, prostate cancer, pancreatic cancer, head and neck cancer (to be defined) | • Diagnostic assay | |
• Personalized immune-treatment |