Fig. 7
From: A Yin-Yang 1/miR-30a regulatory circuit modulates autophagy in pancreatic cancer cells
YY1/miR30a regulates autophagy in pancreatic xenograft tumors. a The in vivo tumorigenicity of PANC-1 cells with or without YY1/miR30a expression was determined using a nude mouse xenograft assay. Results are representative of three independent experiments. b qRT-PCR analysis of miR30a expression in pancreatic xenograft tumors. c ATG5 and Beclin-1 expression and autophagy activity in the YY1-knockdown xenograft samples assayed by Western blotting. Results are representative of three independent experiments. d ATG5 and Beclin-1 expression and autophagy activity in the miR30a-knockdown xenograft samples assayed by Western blotting. Results are representative of three independent experiments. e A model of the YY1/miR-30a regulatory interaction during autophagy in pancreatic cancer cells