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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: A Yin-Yang 1/miR-30a regulatory circuit modulates autophagy in pancreatic cancer cells

Fig. 6

miR-30a acts in a feedback loop to inhibit YY1. a Predicted binding sites for miR-30a in the YY1 3′UTR. The engineered mutant sequence is also shown. b The luciferase activities of BXPC-3 and PANC-1 cells were measured after co-transfection with the indicated YY1 3′UTR constructs and miR-30a for 24 h. c Western blot and qRT-PCR analysis of YY1 protein or mRNA levels in BXPC-3 and PANC-1 cells transfected with miR-30a-overexpressing or -inhibiting lentivirus. **p < 0.01, ***p < 0.001

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