Fig. 3

Peripheral blood vessel density (BVD), peritumoral lymph vessel density (LVD), tumor growth curves, and tumor volume doubling time (T _d) of two groups of human melanoma xenografts differing in metastatic pattern. C-10, D-12, and E-13 tumors did not differ from N-15, R-18, and T-22 tumors in peripheral BVD (a) or peritumoral LVD (b), but grew faster (c) and, hence, had shorter T _d than N-15, R-18, and T-22 tumors (d). Columns and bars: mean values ± standard error (n = 20 in a, b and n = 50 in d, where n represents the number of studied tumors). Symbols and bars in c: Geometric mean ± standard error (n = 50). The experiments were carried out by using adult (8–12 weeks of age) female BALB/c nu/nu mice as host animals