Table 1 Therapeutic antioxidant use in lung diseases
From: The pathophysiological role of mitochondrial oxidative stress in lung diseases
Classification | Antioxidant compounds | Potential lung disease applications |
|---|---|---|
Dietary vitamins | Ascorbic acid Vitamin E β-carotene Selenium All-trans retinoic acid (ATRA) | Asthma, COPD, cigarette smoking, emphysema |
Thiols | Glutathione (GSH) | COPD, asthma |
N-acetyl-l-cysteine (NAC) N-acystelyn (NAL) N-iso-butyryl-cysteine (NIC) | IPF, silicosis, ALI/ARDS, chronic bronchitis | |
Erdosteine Fudosteine | COPD, chronic bronchitis, cigarette smoking | |
Thioredoxin (MOL-294) | Lung cancer | |
Enzyme mimetics | SOD | ALI/ARDS, COPD, cigarette smoking, asthma |
Ebselen | COPD, asthma | |
PDE4 inhibitors | Roflumilast Cilomilast | COPD, asthma, chronic bronchitis |
Polyphenols | Resveratrol Curcumin Quercetin Lycopene Acai | COPD ALI/ARDS |