From: Impact of mesenchymal stem cells’ secretome on glioblastoma pathophysiology
Protein (coding gene) | Findings in the context of cancer cells | References |
---|---|---|
C-C motif chemokine 2 (CCL2) | Regulates migration and invasion in several cancer types, including gliomas | |
Actin-related protein 2/3 complex subunit 5 (ARPC5) | Contributes to cell migration and invasion in head and neck squamous cell carcinoma | [102] |
Translationally-controlled tumor protein (TPT1) | Overexpressed in glioma tissue and is associated with tumor progression and poor clinical outcome of glioma patients. TCTP promotes glioma cell viability and proliferation, in vitro | |
Platelet-derived growth factor C (PDGFC) | Plays an important role in glioma vessel maturation and stabilization and in the progression of brain tumors, such as glioblastoma and medulloblastoma; and promotes tumor growth by recruitment of cancer-associated fibroblasts | |
Alpha-actinin-4 (ACTN4) | Enhances the motility and invasion potential of various carcinoma cell lines | [108] |
Testican-1 (SPOCK1) | Promotes the proliferation, migration and invasion and inhibits apoptosis in glioma cells | [109] |
Neuropilin-2 (NRP2) | Essential for breast cancer tumor initiation being involved in the formation of focal adhesions and is associated with metastasis and poor prognosis; and promotes the invasion and migration of thyroid cancer cells | |
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) | Correlated with the grade of malignancy in human glioma; increases the migration capacity of glioma stem cells, and is implicated in U87 cell invasiveness | |
Transforming growth factor-beta-induced protein (TGFβI) | Promotes cell adhesion of human astrocytoma cells, in vitro | [117] |
Plasminogen activator inhibitor 1 (SERPINE1) | Essential in processes related to tumor development, like angiogenesis, adhesion, migration, invasion and metastasis | [118] |
Semaphorin-7A (SEMA7A) | Contributes to the increases motility and decreases adhesion necessary for U87 cell invasion | [114] |
Periostin (POSTN) | Secreted periostin promotes glioma cell invasion and adhesion | [119] |
Interleukin 6 (IL6) | Secreted IL6 promotes glioma cell invasion and angiogenesis |