Fig. 3
From: Impact of mesenchymal stem cells’ secretome on glioblastoma pathophysiology
Effect of HUCPVCs conditioned media (CM) on GBM cell proliferation and sensitivity to temozolomide treatment. a, c Proliferation capacity of U251 (a) and SNB-19 (c) GBM cells was determined by BrdU assay after treatment with control media or HUCPVCs CM. Exposure to HUCPVCs CM increased the proliferation rate of both GBM cell lines (**p ≤ 0.01). b, d Determination of the half inhibitory concentration (IC50) values of temozolomide (TMZ) treatment in U251 (b) and SNB-19 (d) cell lines. For both cell lines, no statistically significant differences in the TMZ IC50 values were found between cells treated with HUCPVCs CM or control media (p = 0.6738 for U251, and p = 0.3115 in SNB-19). Results are expressed as the mean ± SD of 3 independent experiments, each in triplicate