Statistically controlled identification of differentially expressed genes in one-to-one cell line comparisons of the CMAP database for drug repositioning

Table 5 Results of the drug repositioning for phenformin and metformin

Methods	CMAP name	Overlap genes	Reversal score	N	P value
Approach recommended by CMAP	Phenformin_HL60	/^a	− 0.7880	1	1
	Phenformin_MCF7	/^a	0.5070	4	1
	Phenformin_PC3	/^a	− 0.2880	2	0.9887
	Metformin_HL60	/^a	− 0.6700	1	1
	Metformin_MCF7	/^a	− 0.2910	7	0.5039
	Metformin_PC3	/^a	0.4890	2	1
Approach based on OneComp	Phenformin_HL60	1180	0.4271	1	1
	Phenformin_MCF7	489	0.6094	4	< 0.0001
	Phenformin_PC3	190	0.6053	2	0.0023
	Metformin_HL60	1028	0.5564	1	0.0002
	Metformin_MCF7	1296	0.5872	7	< 0.0001
	Metformin_PC3	122	0.6148	2	0.0071

N present the number of the cell samples treated by the phenformin or phenformin at different dose
^aCMAP approach do not provide these data

ISSN: 1479-5876