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Table 5 Results of the drug repositioning for phenformin and metformin

From: Statistically controlled identification of differentially expressed genes in one-to-one cell line comparisons of the CMAP database for drug repositioning

Methods CMAP name Overlap genes Reversal score N P value
Approach recommended by CMAP Phenformin_HL60 /a − 0.7880 1 1
Phenformin_MCF7 /a 0.5070 4 1
Phenformin_PC3 /a − 0.2880 2 0.9887
Metformin_HL60 /a − 0.6700 1 1
Metformin_MCF7 /a − 0.2910 7 0.5039
Metformin_PC3 /a 0.4890 2 1
Approach based on OneComp Phenformin_HL60 1180 0.4271 1 1
Phenformin_MCF7 489 0.6094 4 < 0.0001
Phenformin_PC3 190 0.6053 2 0.0023
Metformin_HL60 1028 0.5564 1 0.0002
Metformin_MCF7 1296 0.5872 7 < 0.0001
Metformin_PC3 122 0.6148 2 0.0071
  1. N present the number of the cell samples treated by the phenformin or phenformin at different dose
  2. aCMAP approach do not provide these data