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Fig. 8 | Journal of Translational Medicine

Fig. 8

From: A lipidated peptide of Mycobacterium tuberculosis resuscitates the protective efficacy of BCG vaccine by evoking memory T cell immunity

Fig. 8

L91 elicits long lasting Th1 and Th17 immune response of BCG vaccinated volunteers. PBMCs of BCG vaccinated human subjects were stimulated with L91 and control cultures with Pam2Cys and medium for 96 h and analyzed for the expression of memory markers and cytokines by flow cytometer. a Histogram and b scatter plot depicts percent population CD4 T cell expressing IFN-γ (n = 16). Likewise, c scatter dot plot represents percent population of CD4 T cell expressing IL-17A (n = 9). d Polyfunctional T cells were identified on CD4 gated T cells co-expressing IFN-γ and IL-17A (n = 9). e Histogram and f scatter dot plot represent the percentage of CD45RA+CD45RO+ memory CD4 T cells in BCG immunized human subjects (n = 14). Data are shown as Mean ± SEM. **p ≤ 0.005, ***p ≤ 0.0005, ns not significant

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