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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: A lipidated peptide of Mycobacterium tuberculosis resuscitates the protective efficacy of BCG vaccine by evoking memory T cell immunity

Fig. 5

Prime boosting with BCG-L91 improves the protective efficacy of BCG. Animals were vaccinated with BCG and later boosted twice with L91. Ninety days of last booster, the mice were aerosol challenged with Mtb. After 90 days, bacterial burden was enumerated in the a lungs and b spleen. Control animals received saline, LH and BCG. The bacterial number is expressed as log10CFU/g of tissue. Results shown as bar diagram are Mean ± SEM and pooled data from 3 experiments (n = 3 mice/group). c Histopathological analysis of lung was done after staining the sections with hematoxylin and eosin. The magnification is depicted at 20 ×/100 × for lungs. The arrows indicate granulomas or tubercle. The asterisk represents the level of significance. d The quantitative assessment of the Mtb infected lungs was done by counting the granulomas in ten random fields of the gross histopathological sections and the average is expressed as Mean ± SD. LH lipidated hemagglutinin peptide, BCG-L91 mice primed with BCG and boosted with L91. **p ≤ 0.005, ***p ≤ 0.0005, ns not significant

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