Fig. 8From: Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertensionMolecular proof of cardiac hypertrophy and fibrosis, by myocardial gene expression of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and SERCA2a and microRNA-1 and 29 expression in left (LV) and right ventricle (RV) of pigs with cardiac hypertrophy compared to controls. a Gene expression in LV, RV, left atrium (LA), and right atrium (RA) of pigs with cardiac hypertrophy (HYPI) induced by aortic isthmus stenosis 5 months after stent implantation. ANP and BNP are up regulated in the LV, and the calcium ATPase SERCA2a showed diminished expression in the LA. b Significant alteration of the miRNA expression pattern was detected, including down regulation of miR-1 and upregulation of miR-29a in both ventricles. Results are expressed as mean ± SD, *p < 0.05 (ANOVA) between the groups (n = 7, HYPI, n = 5, control)Back to article page