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Fig. 8 | Journal of Translational Medicine

Fig. 8

From: Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension

Fig. 8

Molecular proof of cardiac hypertrophy and fibrosis, by myocardial gene expression of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and SERCA2a and microRNA-1 and 29 expression in left (LV) and right ventricle (RV) of pigs with cardiac hypertrophy compared to controls. a Gene expression in LV, RV, left atrium (LA), and right atrium (RA) of pigs with cardiac hypertrophy (HYPI) induced by aortic isthmus stenosis 5 months after stent implantation. ANP and BNP are up regulated in the LV, and the calcium ATPase SERCA2a showed diminished expression in the LA. b Significant alteration of the miRNA expression pattern was detected, including down regulation of miR-1 and upregulation of miR-29a in both ventricles. Results are expressed as mean ± SD, *p < 0.05 (ANOVA) between the groups (n = 7, HYPI, n = 5, control)

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