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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension

Fig. 6

Macroscopic and microscopic imaging of the aortic isthmus stenosis, myocardial hypertrophy and fibrosis. a Explanted descending aorta shows pre- and poststenotic dilation of the corresponding aorta segments 5-month after stent implantation (arrow). b Longitudinal cut of the aorta displays the stent in the aorta. c and d Left ventricular myocardium in a control animal and in a hypertrophic pig (HYPI), showing severe concentric hypertrophy in the HYPI animal. e Anti-collagen staining of the hypertrophied myocardium shows collagen accumulation as a proof of myocardial fibrosis. (left: anti-collagen staining, right: DAPI counterstaining, bottom: merged). f Histologic images of the left ventricle (LV) and right ventricle (RV) of hypertrophic (HYPI) and control animals. HE, Picrosirius red and MOVAT staining display pronounced interstitial fibrosis in the HYPI animals both in the LV and RV. g Quantification of fibrosis of the myocardial samples: significantly higher amount of fibrosis in the HYPI animals. Mean ± SD, *p < 0.05 (ANOVA) between the control (n = 5) and HYPI groups (n = 7)

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