Fig. 5

BDNF/TrKB axis activation on transcriptional factors and ECM markers. a mRNA levels of Zeb, Snail and Twist changes in the presence of BDNF or TrkB receptor blocker K252a. Note the decrease in the mRNA expression in comparison to BDNF treated cell lines. b Zymography assay. Enzyme activity of MPP9 was reduced after k252a treatment. c BDNF effects on cytoplasmic and nuclear expression of the β-catenin protein. Increase of the β-catenin cytoplasmic expression induced by BDNF was inhibited blocking TrKB receptor by K252a (*p = 0.003). The nuclear expression of β-catenin was increased in the presence of BDNF. K252a reverted this effect (**p = 0.0007). UDR: densitometric relative unit