Fig. 1
From: Cancer heterogeneity: converting a limitation into a source of biologic information
Schematic representation of somatic cancer evolution as a phylogenetic tree with early parallel evolution and strong negative selection at later stages of cancer progression. This results in a strong early rise of mutation load and structural rearrangements followed by limited further increase of mutation load after cancer cells have reached a point of maximum tolerable disorder of the genome. Ω indicates extinction of a subclone lineage due to lethal mutations