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Table 5 Proteins affected in diabetes

From: Multiple therapeutic effect of endothelial progenitor cell regulated by drugs in diabetes and diabetes related disorder

Protein affected in diabetes and predicted by PharmMapper

Polymorphism/inhibitors

Function in diabetes

References

eNOS

T786C

G894T

Uncoupling leads to ROS generation

Konsola et al. [173] Int J Cardiol. 2016

Glutathione S transferase

Ile 105Val

Reduces ROS

Mergani et al. [174] Biochem Genet. 2016

Fructose1,6 bisphosphatase

Inhibitor

Gluconeogenesis

Van et al. [175] Handb Exp Pharmacol. 2011

HSp90

Inhibitors

Therapeutic/protective effect for diabetes mediated atherosclerosis

Vazquez et al. [176] Clin Investig Arterioscler. 2017

VEGF

Gene polymorphism

Angiogenesis

Gonzalez et al. [177] Int J Ophthalmol. 2017

Lai et al. [178] Sci Rep. 2017

SDF

Genetic

Cytokine in diabetic foot ulcer

Gene. 2015

Neuraminidase

Novel gene

Positive regulation for insulin signalling

Dridi et al. [179] Diabetes 2013

CDK2

Loss

Beta cell depletion

Kim et al. [180] J Biol Chem. 2017