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Table 3 Drugs that increase EPC number and improve EPC function in diabetes condition

From: Multiple therapeutic effect of endothelial progenitor cell regulated by drugs in diabetes and diabetes related disorder

Drug Signalling pathway targeted Diabetes related disorder References
Vildagliptin SDF Type 2 diabetes Dei et al. [155] Cardiovasc Diabetol. 2017
Elevated CXCR7 Akt/GSK/Fyn Limb ischemia Dai et al.[156] Circ Res. 2017 [224]
Metformin AMPK/NOS Diabetes and wound healing Yu et al. [157] Cardiovasc Diabetol. 2016
Amlodipine VEGF/Akt/eNOS Diabetes Sun et al. [158] Biomed Res Int. 2016
Aliskiren SDF Diabetes Chang et al. [159] PLoS One. 2015[227]
Insulin and Glargine Diabetes Oikonomou et al. [160] Cardiovasc Diabetol. 2014
Ginkgo Biloba extract SOD Diabetes Zhao et al. [161]Genet Mol Res. 2014
Aliskiren Diabetes Raptis et al. [162] Am J Hypertens. 2015
Cathepsin B GSK 3 beta Diabetes Hibbert et al. [163] Diabetes. 2014
Simvastatin eNOS Retinopathy Zhang et al. [164] Exp Eye Res. 2012
Insulin   Diabetes Dong et al. [165] Microvasc Res. 2011
Sitagliptin SDF Diabetes Fadini et al. [166] Diabetes Care. 2010
Adiponectin p38 MAPK/P16INK Diabetes Chang et al.[167] Diabetes. 2010
Pioglitazone ICAM-1/VCAM-1 CV risk in Diabetes Wang et al. [168] Am Heart J. 2006
Vitamin D Diabetes Yiu et al. [169] Atherosclerosis
Acarbose Akt/eNOS Diabetes and wound healing Han et al. [170] Oxid Med Cell Longev
Crocetin PI3K/Akt/ eNOS and ROS Diabetes Cao et al. [171] Life Sci