Table 3 Drugs that increase EPC number and improve EPC function in diabetes condition
Drug | Signalling pathway targeted | Diabetes related disorder | References |
|---|---|---|---|
Vildagliptin | SDF | Type 2 diabetes | Dei et al. [155] Cardiovasc Diabetol. 2017 |
Elevated CXCR7 | Akt/GSK/Fyn | Limb ischemia | Dai et al.[156] Circ Res. 2017 [224] |
Metformin | AMPK/NOS | Diabetes and wound healing | Yu et al. [157] Cardiovasc Diabetol. 2016 |
Amlodipine | VEGF/Akt/eNOS | Diabetes | Sun et al. [158] Biomed Res Int. 2016 |
Aliskiren | SDF | Diabetes | Chang et al. [159] PLoS One. 2015[227] |
Insulin and Glargine | – | Diabetes | Oikonomou et al. [160] Cardiovasc Diabetol. 2014 |
Ginkgo Biloba extract | SOD | Diabetes | Zhao et al. [161]Genet Mol Res. 2014 |
Aliskiren | – | Diabetes | Raptis et al. [162] Am J Hypertens. 2015 |
Cathepsin B | GSK 3 beta | Diabetes | Hibbert et al. [163] Diabetes. 2014 |
Simvastatin | eNOS | Retinopathy | Zhang et al. [164] Exp Eye Res. 2012 |
Insulin | Â | Diabetes | Dong et al. [165] Microvasc Res. 2011 |
Sitagliptin | SDF | Diabetes | Fadini et al. [166] Diabetes Care. 2010 |
Adiponectin | p38 MAPK/P16INK | Diabetes | Chang et al.[167] Diabetes. 2010 |
Pioglitazone | ICAM-1/VCAM-1 | CV risk in Diabetes | Wang et al. [168] Am Heart J. 2006 |
Vitamin D | – | Diabetes | Yiu et al. [169] Atherosclerosis |
Acarbose | Akt/eNOS | Diabetes and wound healing | Han et al. [170] Oxid Med Cell Longev |
Crocetin | PI3K/Akt/ eNOS and ROS | Diabetes | Cao et al. [171] Life Sci |