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Table 4 Multivariate analysis of prognostic value of AML

From: Gene mutational pattern and expression level in 560 acute myeloid leukemia patients and their clinical relevance

Variables CR OS DFS
OR (95% CI) P HR (95% CI) P HR (95% CI) P
Age 0.968 (0.957–0.980) <0.001 1.023 (1.016–1.030) <0.001 1.018 (1.008–1.028) <0.001
WBC   NS   NS   NS
Cytogenetic risk 0.894 (0.800–0.998) 0.046 1.093 (1.032–1.158) 0.002 1.106 (1.019–1.201) 0.016
FLT3-ITD/TKD   NS 1.408 (1.074–1.845) 0.013 1.492 (1.010–2.203) 0.044
Biallelic CEBPA   NS 0.524 (0.325–0.845) 0.008   NS
NPM1-mut/DNMT3A-wt 3.389 (1.519–7.562) 0.003 0.523 (0.355–0.770) 0.001   NS
MLL-PTD   NS   NS   NS
DNMT3A mutation   NS   NS   NS
High MECOM 0.576 (0.377–0.880) 0.011 1.642 (1.296–2.081) <0.001 1.788 (1.319–2.424) <0.001
High MESI1 0.389 (0.251–0.603) <0.001 1.432 (1.114–1.840) 0.005   NS
High SPI1   NS   NS   NS
  1. NS no significance