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Table 4 Multivariate analysis of prognostic value of AML

From: Gene mutational pattern and expression level in 560 acute myeloid leukemia patients and their clinical relevance

Variables

CR

OS

DFS

OR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Age

0.968 (0.957–0.980)

<0.001

1.023 (1.016–1.030)

<0.001

1.018 (1.008–1.028)

<0.001

WBC

 

NS

 

NS

 

NS

Cytogenetic risk

0.894 (0.800–0.998)

0.046

1.093 (1.032–1.158)

0.002

1.106 (1.019–1.201)

0.016

FLT3-ITD/TKD

 

NS

1.408 (1.074–1.845)

0.013

1.492 (1.010–2.203)

0.044

Biallelic CEBPA

 

NS

0.524 (0.325–0.845)

0.008

 

NS

NPM1-mut/DNMT3A-wt

3.389 (1.519–7.562)

0.003

0.523 (0.355–0.770)

0.001

 

NS

MLL-PTD

 

NS

 

NS

 

NS

DNMT3A mutation

 

NS

 

NS

 

NS

High MECOM

0.576 (0.377–0.880)

0.011

1.642 (1.296–2.081)

<0.001

1.788 (1.319–2.424)

<0.001

High MESI1

0.389 (0.251–0.603)

<0.001

1.432 (1.114–1.840)

0.005

 

NS

High SPI1

 

NS

 

NS

 

NS

  1. NS no significance