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Table 3 CR rate of different gene mutation and expression group in intermediate risk group

From: Gene mutational pattern and expression level in 560 acute myeloid leukemia patients and their clinical relevance

Gene mutation CR no (%) Gene expression CR no (%)
FLT3 ITD/TKD MECOM
 Mutated 60 (59.4)  Low 160 (74.4)
 Not mutated 212 (70.7)  High 101 (58.0)
 P 0.036  P 0.001
NRAS MEIS1
 Mutated 25 (78.1)  Low 138 (75.8)
 Not mutated 247 (66.9)  High 134 (61.2)
 P 0.194  P 0.002
C-KIT (NA = 2) SPI1
 Mutated 19 (79.2)  Low 158 (72.5)
 Not mutated 271 (67.9)  High 114 (62.3)
 P 0.223  P 0.030
DNMT3A ERG
 Mutated 33 (61.1)  Low 151 (70.6)
 Not mutated 239 (68.9)  High 121 (64.7)
 P 0.256  P 0.211
IDH1 (NA = 1) WT1
 Mutated 23 (60.5)  Low 136 (70.5)
 Not mutated 249 (68.6)  High 136 (66.0)
 P 0.311  P 0.341
IDH2 GATA2
 Mutated 22 (62.9)  Low 128 (67.7)
 Not mutated 250 (68.3)  High 144 (67.9)
 P 0.510  P 0.966
NPM1/DNMT3A BAALC
 NPM1-mut/DNMT3A-wt 48 (78.7)  Low 159 (69.7)
 Others 224 (65.9)  High 113 (65.3)
 P 0.049  P 0.348
WT1   
 Mutated 26 (76.5)   
 Not mutated 245 (66.9)   
 P 0.255   
CEBPA   
 Biallelic mutated 59 (83.1)   
 Monoallelic mutated 21 (61.8)   
 Not mutated 189 (64.7)   
 P 0.009   
MLL-PTD   
 Mutated 14 (60.9)   
 Not mutated 258 (68.3)   
 P 0.462