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Table 1 Clinical characteristics and gene expression level

From: Gene mutational pattern and expression level in 560 acute myeloid leukemia patients and their clinical relevance

Gene expression

Age (years)

Gender, n (%)

WBC count, ×109/L

Median (range)

≤60, n (%)

>60, n (%)

Male

Female

Median (range)

MECOM (missing = 12)

 Low (n = 274)

42.5 (1–81)

238 (51.4)

36 (42.4)

168 (61.3)

106 (38.7)

14.2 (0.34–453.0)

 High (n = 274)

43 (1–83)

225 (48.6)

49 (57.6)

144 (52.6)

130 (47.4)

13.9 (0.50–376.8)

 P

0.448

 

0.125

0.038

 

0.515

MEIS1

 Low (n = 280)

42 (2–80)

251 (53.0)

29 (33.7)

175 (62.5)

105 (37.5)

13.7 (0.65–453.0)

 High (n = 280)

45 (1–83)

223 (47.0)

57 (66.3)

145 (51.8)

135 (48.2)

15.3 (0.34–389.4)

 P

0.026

 

0.001

0.010

 

0.409

SPI1

 Low (n = 280)

42 (1–81)

246 (51.9)

34 (39.5)

165 (58.9)

115 (41.1)

10.6 (0.5–453.0)

 High (n = 280)

44 (1–83)

228 (48.1)

52 (60.5)

155 (55.4)

125 (44.6)

16.9 (0.34–298.5)

 P

0.113

 

0.035

0.393

 

0.003

ERG

 Low (n = 280)

44 (1–81)

238 (50.2)

42 (48.8)

151 (53.9)

129 (46.1)

13.1 (0.34–389.4)

 High (n = 280)

41 (1–83)

236 (49.8)

44 (51.2)

169 (60.4)

111 (39.6)

15.8 (0.50–453.0)

 P

0.490

 

0.815

0.124

 

0.210

WT1 (missing = 2)

 Low (n = 279)

43 (1–83)

237 (50.2)

42 (48.8)

172 (61.6)

107 (38.4)

13.5 (0.34–376.8)

 High (n = 279)

43 (2–81)

235 (49.8)

44 (51.2)

147 (52.7)

132 (47.3)

16.9 (0.50–453.0)

 P

0.873

 

0.815

0.032

 

0.406

GATA2

 Low (n = 280)

43 (2–83)

239 (50.4)

41 (47.7)

162 (57.9)

118 (42.1)

11.0 (0.34–376.8)

 High (n = 280)

43 (1–81)

235 (49.6)

45 (52.3)

158 (56.4)

122 (43.6)

17.5 (0.50–453.0)

 P

0.832

 

0.639

0.733

 

0.003

BAALC

 Low (n = 280)

45 (1–79)

239 (50.4)

41 (47.7)

153 (54.6)

127 (45.4)

14.2 (0.34–389.4)

 High (n = 280)

41 (1–83)

235 (49.6)

45 (52.3)

167 (59.6)

113 (40.4)

14.1 (0.6–453.0)

 P

0.279

 

0.639

0.232

 

0.878

  1. WBC white blood cell, n number