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Table 1 Clinical characteristics and gene expression level

From: Gene mutational pattern and expression level in 560 acute myeloid leukemia patients and their clinical relevance

Gene expression Age (years) Gender, n (%) WBC count, ×109/L
Median (range) ≤60, n (%) >60, n (%) Male Female Median (range)
MECOM (missing = 12)
 Low (n = 274) 42.5 (1–81) 238 (51.4) 36 (42.4) 168 (61.3) 106 (38.7) 14.2 (0.34–453.0)
 High (n = 274) 43 (1–83) 225 (48.6) 49 (57.6) 144 (52.6) 130 (47.4) 13.9 (0.50–376.8)
 P 0.448   0.125 0.038   0.515
MEIS1
 Low (n = 280) 42 (2–80) 251 (53.0) 29 (33.7) 175 (62.5) 105 (37.5) 13.7 (0.65–453.0)
 High (n = 280) 45 (1–83) 223 (47.0) 57 (66.3) 145 (51.8) 135 (48.2) 15.3 (0.34–389.4)
 P 0.026   0.001 0.010   0.409
SPI1
 Low (n = 280) 42 (1–81) 246 (51.9) 34 (39.5) 165 (58.9) 115 (41.1) 10.6 (0.5–453.0)
 High (n = 280) 44 (1–83) 228 (48.1) 52 (60.5) 155 (55.4) 125 (44.6) 16.9 (0.34–298.5)
 P 0.113   0.035 0.393   0.003
ERG
 Low (n = 280) 44 (1–81) 238 (50.2) 42 (48.8) 151 (53.9) 129 (46.1) 13.1 (0.34–389.4)
 High (n = 280) 41 (1–83) 236 (49.8) 44 (51.2) 169 (60.4) 111 (39.6) 15.8 (0.50–453.0)
 P 0.490   0.815 0.124   0.210
WT1 (missing = 2)
 Low (n = 279) 43 (1–83) 237 (50.2) 42 (48.8) 172 (61.6) 107 (38.4) 13.5 (0.34–376.8)
 High (n = 279) 43 (2–81) 235 (49.8) 44 (51.2) 147 (52.7) 132 (47.3) 16.9 (0.50–453.0)
 P 0.873   0.815 0.032   0.406
GATA2
 Low (n = 280) 43 (2–83) 239 (50.4) 41 (47.7) 162 (57.9) 118 (42.1) 11.0 (0.34–376.8)
 High (n = 280) 43 (1–81) 235 (49.6) 45 (52.3) 158 (56.4) 122 (43.6) 17.5 (0.50–453.0)
 P 0.832   0.639 0.733   0.003
BAALC
 Low (n = 280) 45 (1–79) 239 (50.4) 41 (47.7) 153 (54.6) 127 (45.4) 14.2 (0.34–389.4)
 High (n = 280) 41 (1–83) 235 (49.6) 45 (52.3) 167 (59.6) 113 (40.4) 14.1 (0.6–453.0)
 P 0.279   0.639 0.232   0.878
  1. WBC white blood cell, n number