Fig. 4

Knockdown of CCDC109B suppresses glioma progression in vivo. a HE staining of orthotopic xenografts to verify brain tumor volume. b Kaplan–Meier survival analysis performed with survival data of mice implanted with U87MG-NC and -sh-CCDC109B-1 cells. Log-rank test was used to calculate P values which were <0.05. c Representative IHC images of CCDC109B, Ki-67, MMP2 and MMP9 expression in xenografts sections of cells indicated. Magnification ×200. d Graphic representation of IHC scoring of CCDC109B, Ki-67, MMP2, MMP9 expression in xenograft sections generated from NC and sh-CCDC109B-1 expressing U87MG cells. Data are presented as the mean ± SEM (**P < 0.01, ***P < 0.001)