Characteristics | Amplification | GCN gain | ASCO/CAP criteria | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Negative | Positive | P | CN <4 | 4≤ CN | P | Negative | Equivocal | Positive | P | |
EGFR | ||||||||||
Location | 1.000 | 0.803 | 0.419 | |||||||
Right colon | 91 (97.8%) | 2 (2.2%) | 89 (95.7%) | 4 (4.3%) | 89 (95.7%) | 2 (2.2%) | 2 (2.2%) | |||
Left colon | 124 (97.6%) | 3 (2.4%) | 123 (96.9%) | 4 (3.1%) | 123 (96.9%) | 0 (0%) | 4 (3.1%) | |||
Rectum | 111 (97.4%) | 3 (2.6%) | 111 (97.4%) | 3 (2.6%) | 111 (97.4%) | 0 (0%) | 3 (2.6%) | |||
pTNM stage | 1.000 | 0.429 | 0.045 | |||||||
I–III | 266 (97.4%) | 7 (2.6%) | 265 (97.1%) | 8 (2.9%) | 265 (97.1%) | 0 (0%) | 8 (2.9%) | |||
IV | 60 (98.4%) | 1 (1.6%) | 58 (95.1%) | 3 (4.9%) | 58 (95.1%) | 2 (3.3%) | 1 (1.6%) | |||
MSI status (n = 323) | 1.000 | 0.609 | 1.000 | |||||||
MSS/MSI-L | 288 (97.3%) | 8 (2.7%) | 285 (96.3%) | 11 (3.7%) | 285 (96.3%) | 2 (0.7%) | 9 (3.0%) | |||
MSI-H | 27 (100%) | 0 (0%) | 27 (100%) | 0 (0%) | 27 (100%) | 0 (0%) | 0 (0%) | |||
HER2 | ||||||||||
Location | 0.011 | 0.073 | 0.015 | |||||||
Right colon | 90 (96.8%) | 3 (3.2%) | 89 (95.7%) | 4 (4.3%) | 89 (95.7%) | 1 (1.1%) | 3 (3.2%) | |||
Left colon | 123 (96.9%) | 4 (3.1%) | 117 (92.1%) | 10 (7.9%) | 116 (91.3%) | 7 (5.5%) | 4 (3.1%) | |||
Rectum | 101 (88.6%) | 13 (11.4%) | 99 (86.8%) | 15 (13.2%) | 99 (86.8%) | 2 (1.8%) | 13 (11.4%) | |||
pTNM stage | 1.000 | 0.248 | 0.422 | |||||||
I–III | 256 (93.8%) | 17 (6.2%) | 247 (90.5%) | 26 (9.5%) | 246 (90.1%) | 10 (3.7%) | 17 (6.2%) | |||
IV | 58 (95.1%) | 3 (4.9%) | 58 (95.1%) | 3 (4.9%) | 58 (95.1%) | 0 (0%) | 3 (4.9%) | |||
MSI status (n = 323) | 1.000 | 0.491 | 1.000 | |||||||
MSS/MSI-L | 278 (93.9%) | 18 (6.1%) | 269 (90.9%) | 27 (9.1%) | 268 (90.5%) | 10 (3.4%) | 18 (6.1%) | |||
MSI-H | 26 (96.3%) | 1 (3.7%) | 26 (96.3%) | 1 (3.7%) | 26 (96.3%) | 0 (0%) | 1 (3.7%) | |||
c-MYC | ||||||||||
Location | 0.056 | 0.042 | 0.083 | |||||||
Right colon | 88 (94.6%) | 5 (5.4%) | 82 (88.2%) | 11 (11.8%) | 82 (88.2%) | 6 (6.5%) | 5 (5.4%) | |||
Left colon | 110 (86.6%) | 17 (13.4%) | 96 (75.6%) | 31 (24.4%) | 96 (75.6%) | 13 (10.2%) | 18 (14.2%) | |||
Rectum | 107 (93.9%) | 7 (6.1%) | 96 (84.2%) | 18 (15.8%) | 96 (84.2%) | 11 (9.6%) | 7 (6.1%) | |||
pTNM stage | 0.723 | 0.136 | 0.199 | |||||||
I–III | 250 (91.6%) | 23 (8.4%) | 228 (83.5%) | 45 (16.5%) | 228 (83.5%) | 21 (7.7%) | 24 (8.8%) | |||
IV | 55 (90.2%) | 6 (9.8%) | 46 (75.4%) | 15 (24.6%) | 46 (75.4%) | 9 (14.8%) | 6 (9.8%) | |||
MSI status (n = 323) | 0.491 | 0.061 | 0.155 | |||||||
MSS/MSI-L | 269 (90.9%) | 27 (9.1%) | 240 (81.1%) | 56 (18.9%) | 240 (81.1%) | 28 (9.5%) | 28 (9.5%) | |||
MSI-H | 26 (96.3%) | 1 (3.7%) | 26 (96.3%) | 1 (3.7%) | 26 (96.3%) | 0 (0%) | 1 (3.7%) | |||
MET | ||||||||||
Location | 0.427 | 0.602 | 0.536 | |||||||
Right colon | 87 (93.5%) | 6 (6.5%) | 77 (82.8%) | 16 (17.2%) | 75 (80.6%) | 10 (10.8%) | 8 (8.6%) | |||
Left colon | 122 (96.1%) | 5 (3.9%) | 109 (85.8%) | 18 (14.2%) | 106 (83.5%) | 15 (11.8%) | 6 (4.7%) | |||
Rectum | 111 (97.4%) | 3 (2.6%) | 100 (87.7% | 14 (12.3%) | 99 (86.8%) | 11 (9.6%) | 4 (3.5%) | |||
pTNM stage | 1.000 | 0.003 | 0.020 | |||||||
I–III | 261 (95.6%) | 12 (4.4%) | 241 (88.3%) | 32 (11.7%) | 235 (86.1%) | 23 (8.4%) | 15 (5.5%) | |||
IV | 59 (96.7%) | 2 (3.3%) | 45 (73.8%) | 16 (26.2%) | 45 (73.8%) | 13 (21.3%) | 3 (4.9%) | |||
MSI status (n = 323) | 0.609 | 0.147 | 0.298 | |||||||
MSS/MSI-L | 284 (95.9%) | 12 (4.1%) | 252 (85.1%) | 44 (14.9%) | 247 (83.4%) | 33 (11.1%) | 16 (5.4%) | |||
MSI-H | 27 (100%) | 0 (0%) | 26 (96.3%) | 1 (3.7%) | 26 (96.3%) | 1 (3.7%) | 0 (0%) |