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Table 1 Demographic and clinical features of included subjects

From: Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma

 

Healthy controls

Patients with asthma

P Controls vs. Patients

P CA vs. CVA vs. CVTA

Total

CA

CVA

CTVA

No. of patients

30

87

30

27

30

  

Age, years

44.0 ± 12.8

42.1 ± 13.8

41.4 ± 13.6

45.0 ± 13.2

40.1 ± 14.4

0.501

0.399

Male sex, no. (%)

15 (50)

42 (48)

14 (47)

10 (37)

18 (60)

0.871

0.218

Smoking status

 Smokers, no. (%)

9 (30)

13 (17)

3 (10)

4 (15)

6 (20)

0.069

0.554

 Pack/years

33.1 ± 42.0

20.5 ± 18.9

21.6 ± 25.0

22.5 ± 20.6

21.5 ± 17.4

0.322

0.997

History of atopy, no. (%)

6 (20)

30 (34)

13 (43)

10 (37)

7 (23)

0.138

0.250

BMI, kg/m2

24.3 ± 3.7

23.2 ± 2.8

23.6 ± 2.4

23.7 ± 2.8

22.5 ± 3.1

0.085

0.187

Serum IgE, IU/mL

1.5 ± 0.6

1.9 ± 0.7

1.9 ± 0.8

1.8 ± 0.8

2.0 ± 0.6

0.014

0.668

FEV1, %Predicted

99.1 ± 13.5

85.9 ± 16.1

80.7 ± 14.6

90.5 ± 17.6

87.1 ± 15.0

<0.001

0.062

FEV1/FVC ratio, %

80.6 ± 16.1

75.0 ± 11.5

74.1 ± 8.0

80.0 ± 8.2

71.5 ± 15.3

0.044

0.017

Blood eosinophils, %

2.0 ± 0.9

3.8 ± 6.0

5.6 ± 4.3

4.6 ± 9.5

2.5 ± 1.9

0.485

0.307

Sputum eosinophils, %

0.4 ± 0.8

1.9 ± 2.2

1.5 ± 1.3

2.1 ± 1.5

2.3 ± 3.2

<0.001

0.417

FeNO, ppb

16.1 ± 10.6

27.3 ± 27.6

34.3 ± 33.1

23.6 ± 24.5

23.4 ± 23.3

0.002

0.229

Anxiety and depression

 SAS score

31.8 ± 7.2

42.1 ± 10.8

42.0 ± 10.8

43.3 ± 9.8

41.2 ± 11.9

<0.001

0.763

 SDS score

34.0 ± 11.4

43.8 ± 11.0

44.9 ± 11.3

44.9 ± 8.7

41.6 ± 12.4

<0.001

0.416

  1. Plus–minus values are mean ± SD. Continuous data were compared with the use of the t test and One Way ANOVA, and categorical data were compared with the use of Pearson’s Chi square test. CA classic asthma, CVA cough-variant asthma, CTVA chest tightness variant asthma. The body-mass index (BMI) is the weight in kilograms divided by the square of the height in meters. FEV 1 forced expiratory volume in 1 s, FVC forced vital capacity, FeNO fractional exhaled nitric-oxide, SAS self-rating anxiety scale, SDS self-rating depression scale