| GLUT1 | HK2 | G6Ptase | LDHA |
---|---|---|---|---|
BJAB cells | ||||
c-MYC-inh. | ||||
ΔΔCT | 1.71 ± 0.11 ↓ | −0.45 ± 0.16 ↑ | −1.69 ± 0.14 ↑ | 1.09 ± 0.14 ↓ |
Fold of untreated | 0.31 (0.28–0.33)* | 1.37 (1.22–1.53)* | 3.23 (2.93–3.56)* | 0.47 (0.43–0.52)* |
LY294002 | ||||
ΔΔCT | 0.03 ± 0.10 | 0.08 ± 0.09 | −0.41 ± 0.10 ↑ | 1.24 ± 0.17 ↓ |
Fold of untreated | 0.98 (0.91–1.06) | 0.95 (0.89–1.01) | 1.33 (1.24–1.42)* | 0.42 (0.38–0.48)* |
Rapamycin | ||||
ΔΔCT | 0.78 ± 0.09 ↓ | 0.84 ± 0.08 ↓ | −0.72 ± 0.17 ↑ | 1.33 ± 0.14 ↓ |
Fold of untreated | 0.58 (0.55–0.62)* | 0.56 (0.53–0.59)* | 1.65 (1.46–1.85)* | 0.40 (0.36–0.44)* |
PD98059 | ||||
ΔΔCT | −0.02 ± 0.13 | 0.01 ± 0.10 | −0.45 ± 0.09 ↑ | 0.04 ± 0.10 |
Fold of untreated | 1.01 (0.93–1.11) | 0.99 (0.93–1.06) | 1.37 (1.28–1.45)* | 0.97 (0.91–1.04) |
SB203580 | ||||
ΔΔCT | 0.01 ± 0.08 | −0.02 ± 0.07 | 0.05 ± 0.11 | −0.09 ± 0.12 |
Fold of untreated | 0.99 (0.94–1.05) | 1.01 (0.97–1.06) | 0.97 (0.90–1.04) | 1.06 (0.98–1.16) |
OCI-LY3 cells | ||||
c-MYC-inh. | ||||
ΔΔCT | 1.12 ± 0.14 ↓ | −0.43 ± 0.12 ↑ | −1.23 ± 0.17 ↑ | 0.78 ± 0.12 ↓ |
Fold of untreated | 0.46 (0.42–0.51)* | 1.35 (1.24–1.46)* | 2.35 (2.08–2.64)* | 0.58 (0.54–0.63)* |
LY294002 | ||||
ΔΔCT | 0.13 ± 0.15 | −0.04 ± 0.10 | −0.60 ± 0.10 ↑ | 1.03 ± 0.14 ↓ |
Fold of untreated | 0.91 (0.82–1.01) | 1.03 (0.96–1.10) | 1.52 (1.41–1.62)* | 0.49 (0.44–0.54)* |
Rapamycin | ||||
ΔΔCT | 0.49 ± 0.13 ↓ | 0.98 ± 0.15 ↓ | −0.97 ± 0.10 ↑ | 1.56 ± 0.20 ↓ |
Fold of untreated | 0.71 (0.65–0.78)* | 0.51 (0.46–0.56)* | 1.96 (1.83–2.10)* | 0.34 (0.30–0.39)* |
PD98059 | ||||
ΔΔCT | −0.03 ± 0.18 | 0.01 ± 0.13 | −0.03 ± 0.08 | 0.01 ± 0.16 |
Fold of untreated | 1.02 (0.90–1.16) | 0.99 (0.91–1.09) | 1.02 (0.97–1.08) | 0.99 (0.89–1.11) |
SB203580 | ||||
ΔΔCT | 0.16 ± 0.14 | 0.44 ± 0.12 ↓ | −0.08 ± 0.13 | −0.03 ± 0.08 |
Fold of untreated | 0.90 (0.81–0.99) | 0.74 (0.68–0.80)* | 1.06 (0.97–1.16) | 1.02 (0.97–1.08) |
SU-DHL-6 cells | ||||
c-MYC-inh. | ||||
ΔΔCT | 1.23 ± 0.12 ↓ | −0.36 ± 0.07 ↑ | −0.93 ± 0.12 ↑ | 1.19 ± 0.08 ↓ |
Fold of untreated | 0.43 (0.39–0.46)* | 1.28 (1.22–1.35)* | 1.91 (1.75–2.07)* | 0.44 (0.41–0.46)* |
LY294002 | ||||
ΔΔCT | −0.11 ± 0.11 | −0.05 ± 0.14 | 0.51 ± 0.08 ↑ | 0.98 ± 0.11 ↓ |
Fold of untreated | 1.08 (1.00–1.16) | 1.04 (0.94–1.14) | 1.42 (1.35–1.51)* | 0.51 (0.47–0.55)* |
Rapamycin | ||||
ΔΔCT | 0.66 ± 0.09 ↓ | −0.83 ± 0.16 ↓ | −0.82 ± 0.16 ↑ | 0.85 ± 0.09 ↓ |
Fold of untreated | 0.63 (0.59–0.67)* | 0.56 (0.50–0.63)* | 1.77 (1.58–1.97)* | 0.55 (0.52–0.59)* |
PD98059 | ||||
ΔΔCT | 0.04 ± 0.16 | 0.09 ± 0.11 | −0.05 ± 0.13 | 0.30 ± 0.10 ↓ |
Fold of untreated | 0.97 (0.87–1.09) | 0.94 (0.87–1.01) | 1.04 (0.95–1.13) | 0.81 (0.76–0.87)* |
SB203580 | ||||
ΔΔCT | −0.08 ± 0.15 | 0.05 ± 0.09 | 0.14 ± 0.14 | 0.17 ± 0.17 |
Fold of untreated | 1.06 (0.95–1.17) | 0.97 (0.91–1.03) | 0.91 (0.82–1.00) | 0.89 (0.79–1.00) |