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Table 2 Cox proportional hazards analysis of the impact of investigated cell populations on overall survival according to morphology

From: The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by morphological subtype

 

Whole cohort

I-type

PB-type

N events

HR (95% CI)

P

N events

HR (95% CI)

P

N events

HR (95% CI)

P

CD1a+ TIDC

 Univariable

  

0.180

 

1

0.826

  

0.031

  Low

153 (100)

1

 

56 (28)

0.85

 

97 (72)

1

 

  High

15 (12)

1.02 (0.82–2.93)

 

5 (2)

(0.20–3.59)

 

10 (10)

2.09 (1.07–4.09)

 Multivariable

  

0.271

  

0.532

  

0.022

  Low

153 (100)

1

 

56 (28)

1

 

97 (72)

1

 

  High

15 (12)

1.42 (0.76–2.67)

 

5 (2)

0.60 (0.12–2.98)

 

10 (10)

2.35 (1.13–4.87)

 

CD68+ TAM

 Univariable

  

0.029

  

0.341

  

0.180

  Low

137 (86)

1

 

55 (26)

1

 

82 (60)

1

 

  High

29 (24)

1.67 (1.06–2.63)

 

6 (4)

1.68 (0.77–4.91)

 

23 (20)

1.42 (0.85–2.35)

 

 Multivariable

  

0.102

  

0.501

  

0.125

  Low

137 (86)

1

 

55 (26)

1

 

82 (60)

1

 

  High

29 (24)

1.48 (0.93–2.36)

 

6 (4)

1.63 (0.39–6.74)

 

23 (20)

1.52 (0.89–2.67)

 

CD163+ TAM

 Univariable

  

0.022

  

0.174

  

0.346

  Low

36 (17)

1

 

20 (7)

1

 

16 (10)

1

 

  High

126 (89)

1.84 (1.09–3.09)

 

40 (22)

1.81 (0.77–4.24)

 

86 (67)

1.38 (0.71–2.68)

 

 Multivariable

  

0.164

  

0.067

  

0.608

  Low

36 (17)

1

 

20 (7)

1

 

16 (10)

1

 

  High

126 (89)

1.46 (0.85–2.57)

 

40 (22)

2.52 (0.94–6.81)

 

86 (67)

1.27 (0.58–2.58)

 

MARCO+

 Univariable

  

0.195

  

0.042

  

0.718

  Low

110 (68)

1

 

38 (14)

1

 

72 (54)

1

 

  High

57 (43)

1.29 (0.88–1.89)

 

22 (15)

2.14 (1.03–4.44)

 

35 (28)

1.09 (0.69-1.72)

 

 Multivariable

  

0.002

 

1

0.220

 

1

0.124

  Low

110 (68)

1

 

38 (14)

  

72 (54)

  

  High

57 (68)

1.95 (1.28–2.98)

 

22 (15)

1.97 (0.67–5.80)

 

35 (28)

1.52 (0.89–2.59)

 
  1. Italics HRs and p values indicate significant values. Adjusted analysis included age (continuous), T-stage (1–2 vs 3–4), N-stage, differentiation grade (poor vs well- moderate), lymphatic invasion, vascular invasion, perineural growth, tumour morphology (I-type/PB-type) and adjuvant therapy (yes/no). Five cases were excluded due to neoadjuvant treatment, on the basis of death due to complications after surgical treatment or emigration
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Journal of Translational Medicine

ISSN: 1479-5876

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