Skip to main content

Table 2 The greatest fold change in miRNA expression levels in the blood of patient with TOF-all, TOF-noHF, and TOF-HF compared to age matched healthy controls as determined by microarray (unpaired two-tailed t test, >2.0-fold difference, and FDR, P < 0.05)

From: Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure

miRNA P value Corrected P value Fold change Regulation AUC
A) TOF-all patients (n = 21) compared to matched healthy controls (n = 15)
 hsa-miR-1231 0.000379 0.001621 6.94 Up 0.83
 hsa-miR-144* 0.000248 0.001198 4.82 Up 0.83
 hsa-miR-505* 0.000557 0.002201 4.61 Up 0.83
 hsa-miR-625 0.007441 0.017478 3.43 Up 0.77
 hsa-miR-15b 0.000412 0.001738 3.03 Up 0.83
 hsa-miR-218-1* 0.001196 0.003935 2.94 Up 0.87
 hsa-miR-214 0.009782 0.021589 2.93 Up 0.75
 hsa-let-7a 0.000013 0.000158 2.66 Up 0.91
 hsa-let-7f 0.000643 0.002493 2.46 Up 0.84
 hsa-miR-20b 0.000040 0.000335 2.41 Up 0.88
 hsa-miR-1274b 0.000002 0.000056 2.38 Up 0.92
 hsa-miR-218-2* 0.000000 0.000016 2.31 Up 0.95
 hsa-let-7g 0.000008 0.000120 2.29 Up 0.90
 hsa-miR-1274a 0.000138 0.000775 2.27 Up 0.86
 hsa-let-7d 0.000012 0.000151 2.26 Up 0.92
 hsa-miR-1233 0.000100 0.000613 2.23 Up 0.83
 hsa-miR-183 0.000221 0.001107 2.21 Up 0.89
 hsa-miR-20a 0.000099 0.000609 2.21 Up 0.86
 hsa-miR-1288 0.000019 0.000195 2.20 Up 0.89
 hsa-miR-138-1* 0.000006 0.000106 2.19 Up 0.90
 hsa-miR-4286 0.003120 0.008467 2.18 Up 0.75
 hsa-miR-3198 0.000335 0.001482 2.12 Up 0.83
 hsa-miR-1181 0.000180 0.000939 2.09 Up 0.85
 hsa-miR-34c-3p 0.000070 0.000488 2.07 Up 0.83
 hsa-miR-3690 0.000000 0.000010 2.05 Up 0.99
 hsa-miR-3125 0.000161 0.000862 2.04 Up 0.83
 hsa-let-7b 0.011673 0.025119 2.00 Up 0.73
 hsa-miR-181d 0.000014 0.000164 5.52 Down 0.05
 hsa-miR-3653 0.002113 0.006271 4.28 Down 0.21
 hsa-miR-206 0.000000 0.000018 2.82 Down 0.07
 hsa-miR-3201 0.006986 0.016505 2.69 Down 0.16
 hsa-miR-142-5p 0.000475 0.001951 2.60 Down 0.19
 hsa-miR-181b 0.000777 0.002851 2.56 Down 0.17
 hsa-miR-194 0.000000 0.000016 2.49 Down 0.06
 hsa-miR-339-5p 0.000000 0.000016 2.43 Down 0.03
 hsa-miR-26a 0.002104 0.006259 2.36 Down 0.20
 hsa-miR-1268 0.011120 0.024188 2.33 Down 0.22
 hsa-miR-595 0.000358 0.001548 2.31 Down 0.17
 hsa-miR-151-3p 0.000000 0.000016 2.20 Down 0.04
 hsa-miR-4271 0.000012 0.000155 2.19 Down 0.10
 hsa-miR-1307 0.002101 0.006259 2.16 Down 0.25
 hsa-miR-222 0.000258 0.001225 2.16 Down 0.14
 hsa-miR-30c 0.000058 0.000432 2.15 Down 0.13
 hsa-miR-620 0.000001 0.000034 2.11 Down 0.07
 hsa-miR-623 0.000312 0.001418 2.09 Down 0.12
 hsa-miR-30b 0.000336 0.001482 2.04 Down 0.15
 hsa-miR-3689b* 0.000000 0.000020 2.04 Down 0.03
 hsa-miR-186 0.009757 0.021573 2.03 Down 0.29
 hsa-miR-191 0.000000 0.000021 2.00 Down 0.06
B) TOF-noHF patients (n = 18) compared to matched healthy controls (n = 15)
 hsa-miR-1231 0.000171 0.000930 8.72 Up 0.86
 hsa-miR-144* 0.000156 0.000861 7.39 Up 0.85
 hsa-miR-505* 0.000551 0.002170 4.54 Up 0.83
 hsa-miR-214 0.009722 0.021817 3.33 Up 0.76
 hsa-miR-625 0.014818 0.031162 3.23 Up 0.76
 hsa-miR-218-1* 0.000048 0.000374 3.18 Up 0.95
 hsa-miR-15b 0.000582 0.002270 3.00 Up 0.82
 hsa-miR-1233 0.000043 0.000353 2.91 Up 0.86
 hsa-let-7a 0.000011 0.000160 2.66 Up 0.92
 hsa-miR-34c-3p 0.000112 0.000674 2.61 Up 0.85
 hsa-let-7f 0.000702 0.002621 2.58 Up 0.84
 hsa-miR-218-2* 0.000000 0.000019 2.58 Up 0.96
 hsa-miR-138-1* 0.000011 0.000160 2.48 Up 0.90
 hsa-miR-20b 0.000262 0.001258 2.48 Up 0.86
 hsa-miR-20a 0.000391 0.001640 2.48 Up 0.84
 hsa-miR-1181 0.000394 0.001643 2.34 Up 0.85
 hsa-miR-4286 0.001466 0.004576 2.32 Up 0.78
 hsa-miR-1274b 0.000003 0.000076 2.31 Up 0.91
 hsa-let-7d 0.000019 0.000225 2.24 Up 0.91
 hsa-miR-3690 0.000000 0.000019 2.23 Up 0.99
 hsa-miR-1292 0.001251 0.004106 2.21 Up 0.75
 hsa-miR-4258 0.000014 0.000189 2.20 Up 0.91
 hsa-miR-1274a 0.000381 0.001627 2.18 Up 0.85
 hsa-miR-1288 0.000089 0.000575 2.16 Up 0.87
 hsa-miR-183 0.000371 0.001597 2.11 Up 0.87
 hsa-miR-4319 0.000039 0.000333 2.10 Up 0.86
 hsa-let-7g 0.000031 0.000290 2.08 Up 0.90
 hsa-miR-124* 0.000023 0.000235 2.06 Up 0.94
 hsa-miR-887 0.000004 0.000079 2.04 Up 0.91
 hsa-miR-921 0.000003 0.000067 2.02 Up 0.90
 hsa-miR-3907 0.000430 0.001761 2.02 Up 0.84
 hsa-miR-196b* 0.000000 0.000019 2.01 Up 0.96
 hsa-let-7b 0.006964 0.016423 2.01 Up 0.76
 hsa-miR-181d 0.000015 0.000204 5.34 Down 0.06
 hsa-miR-3653 0.005185 0.012829 3.99 Down 0.23
 hsa-miR-206 0.000001 0.000035 2.88 Down 0.07
 hsa-miR-194 0.000000 0.000019 2.70 Down 0.06
 hsa-miR-3201 0.003859 0.010042 2.67 Down 0.14
 hsa-miR-181b 0.000658 0.002515 2.62 Down 0.17
 hsa-miR-339-5p 0.000000 0.000019 2.51 Down 0.03
 hsa-miR-26a 0.001287 0.004168 2.38 Down 0.19
 hsa-miR-595 0.000403 0.001676 2.36 Down 0.17
 hsa-miR-151-3p 0.000000 0.000019 2.28 Down 0.04
 hsa-miR-1307 0.001320 0.004219 2.24 Down 0.23
 hsa-miR-3689b* 0.000003 0.000069 2.15 Down 0.03
 hsa-miR-191 0.000001 0.000025 2.15 Down 0.06
 hsa-miR-142-5p 0.001336 0.004247 2.14 Down 0.21
 hsa-miR-222 0.000341 0.001515 2.12 Down 0.15
 hsa-miR-620 0.000001 0.000035 2.11 Down 0.06
 hsa-miR-3129 0.000021 0.000234 2.08 Down 0.09
 hsa-miR-186 0.025390 0.049030 2.08 Down 0.33
 hsa-miR-30c 0.000279 0.001306 2.07 Down 0.16
 hsa-miR-4271 0.000009 0.000143 2.06 Down 0.10
 hsa-miR-140-3p 0.000004 0.000079 2.06 Down 0.05
 hsa-miR-190b 0.000024 0.000241 2.05 Down 0.08
 hsa-miR-623 0.000389 0.001640 2.04 Down 0.13
 hsa-miR-1262 0.000000 0.000020 2.03 Down 0.04
 hsa-miR-30d 0.000018 0.000218 2.01 Down 0.10
C) TOF-HF patients (n = 3) compared to matched healthy controls (n = 3)
 hsa-miR-625 0.000868 0.040212 11.77 Up  
 hsa-miR-183* 0.041803 0.150816 6.16 Up  
 hsa-miR-183 0.016584 0.093166 6.08 Up  
 hsa-miR-505* 0.020963 0.105695 5.66 Up  
 hsa-miR-214 0.000609 0.032735 4.60 Up  
 hsa-miR-30e* 0.015156 0.089838 4.59 Up  
 hsa-let-7d 0.003245 0.062067 4.44 Up  
 hsa-miR-340* 0.045108 0.154000 3.94 Up  
 hsa-miR-28-5p 0.009640 0.081007 3.81 Up  
 hsa-miR-15b 0.000038 0.015689 3.81 Up  
 hsa-miR-151-5p 0.000976 0.040600 3.77 Up  
 hsa-let-7a 0.043951 0.153067 3.51 Up  
 hsa-miR-1271 0.001328 0.044227 3.34 Up  
 hsa-miR-192 0.001655 0.044227 3.30 Up  
 hsa-miR-20b 0.011702 0.083679 3.03 Up  
 hsa-miR-23b 0.001013 0.040600 3.02 Up  
 hsa-miR-148b 0.014520 0.089728 2.95 Up  
 hsa-miR-339-3p 0.006304 0.071105 2.89 Up  
 hsa-let-7g 0.016852 0.093166 2.85 Up  
 hsa-miR-660 0.010161 0.081084 2.71 Up  
 hsa-miR-20a 0.035924 0.135700 2.69 Up  
 hsa-miR-502-3p 0.000625 0.032735 2.60 Up  
 hsa-miR-7-1* 0.002495 0.054656 2.59 Up  
 hsa-miR-3677 0.014330 0.089658 2.55 Up  
 hsa-miR-1274b 0.027516 0.119268 2.49 Up  
 hsa-miR-218-2* 0.004335 0.064409 2.49 Up  
 hsa-miR-18a 0.006475 0.071578 2.38 Up  
 hsa-miR-330-3p 0.004056 0.064314 2.36 Up  
 hsa-miR-1274a 0.004302 0.064409 2.32 Up  
 hsa-miR-29a 0.005922 0.070658 2.31 Up  
 hsa-miR-138-1* 0.000786 0.039488 2.30 Up  
 hsa-miR-744 0.000059 0.015689 2.28 Up  
 hsa-miR-132 0.007974 0.075066 2.19 Up  
 hsa-miR-1181 0.000288 0.024545 2.19 Up  
 hsa-miR-29c 0.026647 0.117616 2.17 Up  
 hsa-miR-3195 0.029339 0.121421 2.16 Up  
 hsa-miR-24 0.007116 0.073136 2.13 Up  
 hsa-miR-3125 0.004598 0.064409 2.10 Up  
 hsa-miR-3127 0.004650 0.064409 2.05 Up  
 hsa-miR-192* 0.000160 0.022287 2.04 Up  
 hsa-miR-1288 0.004046 0.064314 2.03 Up  
 hsa-miR-200c 0.000842 0.040212 2.01 Up  
 hsa-miR-3653 0.000338 0.024640 9.35 Down  
 hsa-miR-181d 0.001044 0.040600 6.90 Down  
 hsa-miR-1268 0.001753 0.044227 4.61 Down  
 hsa-miR-222 0.011501 0.083679 4.47 Down  
 hsa-miR-623 0.007440 0.073136 4.14 Down  
 hsa-miR-574-5p 0.000088 0.017647 3.58 Down  
 hsa-miR-92a 0.000166 0.022287 3.37 Down  
 hsa-miR-99b 0.025374 0.114210 3.36 Down  
 hsa-miR-548f 0.000032 0.015689 3.06 Down  
 hsa-miR-564 0.003564 0.063109 2.88 Down  
 hsa-miR-320a 0.025932 0.115734 2.87 Down  
 hsa-miR-206 0.000138 0.022287 2.80 Down  
 hsa-miR-181a 0.017001 0.093166 2.78 Down  
 hsa-miR-3663-5p 0.014980 0.089808 2.77 Down  
 hsa-miR-595 0.005164 0.068567 2.66 Down  
 hsa-miR-942 0.029072 0.121421 2.65 Down  
 hsa-miR-494 0.003770 0.063109 2.61 Down  
 hsa-miR-423-5p 0.007923 0.075066 2.59 Down  
 hsa-miR-142-5p 0.025401 0.114210 2.52 Down  
 hsa-miR-1228* 0.000065 0.015689 2.52 Down  
 hsa-miR-532-3p 0.016610 0.093166 2.41 Down  
 hsa-miR-670 0.001332 0.044227 2.41 Down  
 hsa-miR-3191 0.007583 0.073136 2.38 Down  
 hsa-miR-452* 0.003478 0.062543 2.35 Down  
 hsa-miR-940 0.001816 0.044648 2.28 Down  
 hsa-miR-30c 0.001368 0.044227 2.27 Down  
 hsa-miR-4316 0.013200 0.087753 2.25 Down  
 hsa-miR-145 0.010675 0.082458 2.25 Down  
 hsa-miR-1306 0.005642 0.068843 2.19 Down  
 hsa-miR-186 0.007169 0.073136 2.15 Down  
 hsa-miR-3147 0.000301 0.024545 2.14 Down  
 hsa-miR-425 0.005463 0.068567 2.08 Down  
 hsa-miR-3686 0.007328 0.073136 2.08 Down  
 hsa-miR-874 0.023395 0.112764 2.02 Down  
 hsa-miR-920 0.029734 0.121421 2.01 Down  
  1. TOF-all all patients with Tetralogy of Fallot, TOF-noHF TOF patients without heart failure, TOF-HF TOF patients with heart failure, AUC area under the receiver operating characteristic curve
  2. * P ≤ 0.05