Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure

Abu-Halima, Masood; Meese, Eckart; Keller, Andreas; Abdul-Khaliq, Hashim; Rädle-Hurst, Tanja

doi:10.1186/s12967-017-1255-z

Journal of Translational Medicine

Table 2 The greatest fold change in miRNA expression levels in the blood of patient with TOF-all, TOF-noHF, and TOF-HF compared to age matched healthy controls as determined by microarray (unpaired two-tailed t test, >2.0-fold difference, and FDR, P < 0.05)

From: Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure

miRNA	P value	Corrected P value	Fold change	Regulation	AUC
A) TOF-all patients (n = 21) compared to matched healthy controls (n = 15)
hsa-miR-1231	0.000379	0.001621	6.94	Up	0.83
hsa-miR-144*	0.000248	0.001198	4.82	Up	0.83
hsa-miR-505*	0.000557	0.002201	4.61	Up	0.83
hsa-miR-625	0.007441	0.017478	3.43	Up	0.77
hsa-miR-15b	0.000412	0.001738	3.03	Up	0.83
hsa-miR-218-1*	0.001196	0.003935	2.94	Up	0.87
hsa-miR-214	0.009782	0.021589	2.93	Up	0.75
hsa-let-7a	0.000013	0.000158	2.66	Up	0.91
hsa-let-7f	0.000643	0.002493	2.46	Up	0.84
hsa-miR-20b	0.000040	0.000335	2.41	Up	0.88
hsa-miR-1274b	0.000002	0.000056	2.38	Up	0.92
hsa-miR-218-2*	0.000000	0.000016	2.31	Up	0.95
hsa-let-7g	0.000008	0.000120	2.29	Up	0.90
hsa-miR-1274a	0.000138	0.000775	2.27	Up	0.86
hsa-let-7d	0.000012	0.000151	2.26	Up	0.92
hsa-miR-1233	0.000100	0.000613	2.23	Up	0.83
hsa-miR-183	0.000221	0.001107	2.21	Up	0.89
hsa-miR-20a	0.000099	0.000609	2.21	Up	0.86
hsa-miR-1288	0.000019	0.000195	2.20	Up	0.89
hsa-miR-138-1*	0.000006	0.000106	2.19	Up	0.90
hsa-miR-4286	0.003120	0.008467	2.18	Up	0.75
hsa-miR-3198	0.000335	0.001482	2.12	Up	0.83
hsa-miR-1181	0.000180	0.000939	2.09	Up	0.85
hsa-miR-34c-3p	0.000070	0.000488	2.07	Up	0.83
hsa-miR-3690	0.000000	0.000010	2.05	Up	0.99
hsa-miR-3125	0.000161	0.000862	2.04	Up	0.83
hsa-let-7b	0.011673	0.025119	2.00	Up	0.73
hsa-miR-181d	0.000014	0.000164	5.52	Down	0.05
hsa-miR-3653	0.002113	0.006271	4.28	Down	0.21
hsa-miR-206	0.000000	0.000018	2.82	Down	0.07
hsa-miR-3201	0.006986	0.016505	2.69	Down	0.16
hsa-miR-142-5p	0.000475	0.001951	2.60	Down	0.19
hsa-miR-181b	0.000777	0.002851	2.56	Down	0.17
hsa-miR-194	0.000000	0.000016	2.49	Down	0.06
hsa-miR-339-5p	0.000000	0.000016	2.43	Down	0.03
hsa-miR-26a	0.002104	0.006259	2.36	Down	0.20
hsa-miR-1268	0.011120	0.024188	2.33	Down	0.22
hsa-miR-595	0.000358	0.001548	2.31	Down	0.17
hsa-miR-151-3p	0.000000	0.000016	2.20	Down	0.04
hsa-miR-4271	0.000012	0.000155	2.19	Down	0.10
hsa-miR-1307	0.002101	0.006259	2.16	Down	0.25
hsa-miR-222	0.000258	0.001225	2.16	Down	0.14
hsa-miR-30c	0.000058	0.000432	2.15	Down	0.13
hsa-miR-620	0.000001	0.000034	2.11	Down	0.07
hsa-miR-623	0.000312	0.001418	2.09	Down	0.12
hsa-miR-30b	0.000336	0.001482	2.04	Down	0.15
hsa-miR-3689b*	0.000000	0.000020	2.04	Down	0.03
hsa-miR-186	0.009757	0.021573	2.03	Down	0.29
hsa-miR-191	0.000000	0.000021	2.00	Down	0.06
B) TOF-noHF patients (n = 18) compared to matched healthy controls (n = 15)
hsa-miR-1231	0.000171	0.000930	8.72	Up	0.86
hsa-miR-144*	0.000156	0.000861	7.39	Up	0.85
hsa-miR-505*	0.000551	0.002170	4.54	Up	0.83
hsa-miR-214	0.009722	0.021817	3.33	Up	0.76
hsa-miR-625	0.014818	0.031162	3.23	Up	0.76
hsa-miR-218-1*	0.000048	0.000374	3.18	Up	0.95
hsa-miR-15b	0.000582	0.002270	3.00	Up	0.82
hsa-miR-1233	0.000043	0.000353	2.91	Up	0.86
hsa-let-7a	0.000011	0.000160	2.66	Up	0.92
hsa-miR-34c-3p	0.000112	0.000674	2.61	Up	0.85
hsa-let-7f	0.000702	0.002621	2.58	Up	0.84
hsa-miR-218-2*	0.000000	0.000019	2.58	Up	0.96
hsa-miR-138-1*	0.000011	0.000160	2.48	Up	0.90
hsa-miR-20b	0.000262	0.001258	2.48	Up	0.86
hsa-miR-20a	0.000391	0.001640	2.48	Up	0.84
hsa-miR-1181	0.000394	0.001643	2.34	Up	0.85
hsa-miR-4286	0.001466	0.004576	2.32	Up	0.78
hsa-miR-1274b	0.000003	0.000076	2.31	Up	0.91
hsa-let-7d	0.000019	0.000225	2.24	Up	0.91
hsa-miR-3690	0.000000	0.000019	2.23	Up	0.99
hsa-miR-1292	0.001251	0.004106	2.21	Up	0.75
hsa-miR-4258	0.000014	0.000189	2.20	Up	0.91
hsa-miR-1274a	0.000381	0.001627	2.18	Up	0.85
hsa-miR-1288	0.000089	0.000575	2.16	Up	0.87
hsa-miR-183	0.000371	0.001597	2.11	Up	0.87
hsa-miR-4319	0.000039	0.000333	2.10	Up	0.86
hsa-let-7g	0.000031	0.000290	2.08	Up	0.90
hsa-miR-124*	0.000023	0.000235	2.06	Up	0.94
hsa-miR-887	0.000004	0.000079	2.04	Up	0.91
hsa-miR-921	0.000003	0.000067	2.02	Up	0.90
hsa-miR-3907	0.000430	0.001761	2.02	Up	0.84
hsa-miR-196b*	0.000000	0.000019	2.01	Up	0.96
hsa-let-7b	0.006964	0.016423	2.01	Up	0.76
hsa-miR-181d	0.000015	0.000204	5.34	Down	0.06
hsa-miR-3653	0.005185	0.012829	3.99	Down	0.23
hsa-miR-206	0.000001	0.000035	2.88	Down	0.07
hsa-miR-194	0.000000	0.000019	2.70	Down	0.06
hsa-miR-3201	0.003859	0.010042	2.67	Down	0.14
hsa-miR-181b	0.000658	0.002515	2.62	Down	0.17
hsa-miR-339-5p	0.000000	0.000019	2.51	Down	0.03
hsa-miR-26a	0.001287	0.004168	2.38	Down	0.19
hsa-miR-595	0.000403	0.001676	2.36	Down	0.17
hsa-miR-151-3p	0.000000	0.000019	2.28	Down	0.04
hsa-miR-1307	0.001320	0.004219	2.24	Down	0.23
hsa-miR-3689b*	0.000003	0.000069	2.15	Down	0.03
hsa-miR-191	0.000001	0.000025	2.15	Down	0.06
hsa-miR-142-5p	0.001336	0.004247	2.14	Down	0.21
hsa-miR-222	0.000341	0.001515	2.12	Down	0.15
hsa-miR-620	0.000001	0.000035	2.11	Down	0.06
hsa-miR-3129	0.000021	0.000234	2.08	Down	0.09
hsa-miR-186	0.025390	0.049030	2.08	Down	0.33
hsa-miR-30c	0.000279	0.001306	2.07	Down	0.16
hsa-miR-4271	0.000009	0.000143	2.06	Down	0.10
hsa-miR-140-3p	0.000004	0.000079	2.06	Down	0.05
hsa-miR-190b	0.000024	0.000241	2.05	Down	0.08
hsa-miR-623	0.000389	0.001640	2.04	Down	0.13
hsa-miR-1262	0.000000	0.000020	2.03	Down	0.04
hsa-miR-30d	0.000018	0.000218	2.01	Down	0.10
C) TOF-HF patients (n = 3) compared to matched healthy controls (n = 3)
hsa-miR-625	0.000868	0.040212	11.77	Up
hsa-miR-183*	0.041803	0.150816	6.16	Up
hsa-miR-183	0.016584	0.093166	6.08	Up
hsa-miR-505*	0.020963	0.105695	5.66	Up
hsa-miR-214	0.000609	0.032735	4.60	Up
hsa-miR-30e*	0.015156	0.089838	4.59	Up
hsa-let-7d	0.003245	0.062067	4.44	Up
hsa-miR-340*	0.045108	0.154000	3.94	Up
hsa-miR-28-5p	0.009640	0.081007	3.81	Up
hsa-miR-15b	0.000038	0.015689	3.81	Up
hsa-miR-151-5p	0.000976	0.040600	3.77	Up
hsa-let-7a	0.043951	0.153067	3.51	Up
hsa-miR-1271	0.001328	0.044227	3.34	Up
hsa-miR-192	0.001655	0.044227	3.30	Up
hsa-miR-20b	0.011702	0.083679	3.03	Up
hsa-miR-23b	0.001013	0.040600	3.02	Up
hsa-miR-148b	0.014520	0.089728	2.95	Up
hsa-miR-339-3p	0.006304	0.071105	2.89	Up
hsa-let-7g	0.016852	0.093166	2.85	Up
hsa-miR-660	0.010161	0.081084	2.71	Up
hsa-miR-20a	0.035924	0.135700	2.69	Up
hsa-miR-502-3p	0.000625	0.032735	2.60	Up
hsa-miR-7-1*	0.002495	0.054656	2.59	Up
hsa-miR-3677	0.014330	0.089658	2.55	Up
hsa-miR-1274b	0.027516	0.119268	2.49	Up
hsa-miR-218-2*	0.004335	0.064409	2.49	Up
hsa-miR-18a	0.006475	0.071578	2.38	Up
hsa-miR-330-3p	0.004056	0.064314	2.36	Up
hsa-miR-1274a	0.004302	0.064409	2.32	Up
hsa-miR-29a	0.005922	0.070658	2.31	Up
hsa-miR-138-1*	0.000786	0.039488	2.30	Up
hsa-miR-744	0.000059	0.015689	2.28	Up
hsa-miR-132	0.007974	0.075066	2.19	Up
hsa-miR-1181	0.000288	0.024545	2.19	Up
hsa-miR-29c	0.026647	0.117616	2.17	Up
hsa-miR-3195	0.029339	0.121421	2.16	Up
hsa-miR-24	0.007116	0.073136	2.13	Up
hsa-miR-3125	0.004598	0.064409	2.10	Up
hsa-miR-3127	0.004650	0.064409	2.05	Up
hsa-miR-192*	0.000160	0.022287	2.04	Up
hsa-miR-1288	0.004046	0.064314	2.03	Up
hsa-miR-200c	0.000842	0.040212	2.01	Up
hsa-miR-3653	0.000338	0.024640	9.35	Down
hsa-miR-181d	0.001044	0.040600	6.90	Down
hsa-miR-1268	0.001753	0.044227	4.61	Down
hsa-miR-222	0.011501	0.083679	4.47	Down
hsa-miR-623	0.007440	0.073136	4.14	Down
hsa-miR-574-5p	0.000088	0.017647	3.58	Down
hsa-miR-92a	0.000166	0.022287	3.37	Down
hsa-miR-99b	0.025374	0.114210	3.36	Down
hsa-miR-548f	0.000032	0.015689	3.06	Down
hsa-miR-564	0.003564	0.063109	2.88	Down
hsa-miR-320a	0.025932	0.115734	2.87	Down
hsa-miR-206	0.000138	0.022287	2.80	Down
hsa-miR-181a	0.017001	0.093166	2.78	Down
hsa-miR-3663-5p	0.014980	0.089808	2.77	Down
hsa-miR-595	0.005164	0.068567	2.66	Down
hsa-miR-942	0.029072	0.121421	2.65	Down
hsa-miR-494	0.003770	0.063109	2.61	Down
hsa-miR-423-5p	0.007923	0.075066	2.59	Down
hsa-miR-142-5p	0.025401	0.114210	2.52	Down
hsa-miR-1228*	0.000065	0.015689	2.52	Down
hsa-miR-532-3p	0.016610	0.093166	2.41	Down
hsa-miR-670	0.001332	0.044227	2.41	Down
hsa-miR-3191	0.007583	0.073136	2.38	Down
hsa-miR-452*	0.003478	0.062543	2.35	Down
hsa-miR-940	0.001816	0.044648	2.28	Down
hsa-miR-30c	0.001368	0.044227	2.27	Down
hsa-miR-4316	0.013200	0.087753	2.25	Down
hsa-miR-145	0.010675	0.082458	2.25	Down
hsa-miR-1306	0.005642	0.068843	2.19	Down
hsa-miR-186	0.007169	0.073136	2.15	Down
hsa-miR-3147	0.000301	0.024545	2.14	Down
hsa-miR-425	0.005463	0.068567	2.08	Down
hsa-miR-3686	0.007328	0.073136	2.08	Down
hsa-miR-874	0.023395	0.112764	2.02	Down
hsa-miR-920	0.029734	0.121421	2.01	Down

TOF-all all patients with Tetralogy of Fallot, TOF-noHF TOF patients without heart failure, TOF-HF TOF patients with heart failure, AUC area under the receiver operating characteristic curve
* P ≤ 0.05

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