Fig. 2

Global immunome analysis reveals differences between AML patients after chemotherapy and age/sex matched healthy donors. a Box and whisker plots of multi-parameter flow cytometry data. Frequencies of subpopulations T-cells, B-cells, dendritic cells, and monocytes were tabulated as a percentage of the average frequency of each cell population in HD. Blue dotted line indicates the normalized average in HD. Red plots mark populations where mean cell frequencies significantly (p < 0.05 with multiple testing correction) differed between AML (n = 10) and HD (n = 10). b Heat map generated from a supervised clustering of gene expression data. Each column represents an individual subject; each row represents a gene. First 8 columns are AML-NR, next 2 columns are AML-R, and last 10 columns are HD. All data represents baseline gene expression. The genes were filtered using criteria of absolute value of log-fold-change higher than 0.2 and FDR-adjusted p value less than 0.05. Up- and down-regulated genes are noted by colors indicated in color key