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Table 2 Simon’s two-stage optimum design

From: A phase I/II trial of fixed-dose stereotactic body radiotherapy with sequential or concurrent pembrolizumab in metastatic urothelial carcinoma: evaluation of safety and clinical and immunologic response

Optimal two stage design Optimum design
First stage sample size (n1) 10
r1 2
Maximum sample size (n) 23
r2 6