Fig. 1

Schematic drawing of CSPG4 protein. CS chondroitin sulfate, D1, D2 and D3 subdomains of the extracellular portion, TM transmembrane domain, ICD intracellular domain, LGR laminin G-type regions, PRR proline-rich region, PDZ PDZ binding domain. The most important molecules interacting with each subdomain of CSPG4 are indicated on the right. RTK receptor tyrosine kinase, ECM extracellular matrix, FGF fibroblast growth factors, PDGF platelet-derived growth factor, PKC protein kinase C, ERK extracellular signal-regulated kinases