Table 2 Diagnostic performance of OXR1, OXR1&MST1R, and HOXA9 promoter methylation in different clinical settings
SE (%) | SP (%) | PPV (%) | NPV (%) | Accuracy (%) | |
|---|---|---|---|---|---|
Normal vs tumour | |||||
OXR1 methylation | 87 | 100 | 100 | 36 | 88 |
OXR1&MST1R methylation | 98 | 100 | 100 | 75 | 98 |
HOXA9 methylation | 73 | 89 | 99 | 20 | 74 |
ccRCC vs RCT | |||||
OXR1 methylation | 80 | 93 | 80 | 93 | 90 |
OXR1&MST1R methylation | 90 | 98 | 93 | 97 | 96 |
RO vs pRCC&chRCC | |||||
HOXA9 methylation | 20 | 95 | 67 | 70 | 70 |