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Table 2 Diagnostic performance of OXR1, OXR1&MST1R, and HOXA9 promoter methylation in different clinical settings

From: Identification of clear cell renal cell carcinoma and oncocytoma using a three-gene promoter methylation panel

  SE (%) SP (%) PPV (%) NPV (%) Accuracy (%)
Normal vs tumour
 OXR1 methylation 87 100 100 36 88
 OXR1&MST1R methylation 98 100 100 75 98
 HOXA9 methylation 73 89 99 20 74
ccRCC vs RCT
 OXR1 methylation 80 93 80 93 90
 OXR1&MST1R methylation 90 98 93 97 96
RO vs pRCC&chRCC
 HOXA9 methylation 20 95 67 70 70
  1. SE sensitivity, SP specificity, PPV positive predictive value, NPV negative predictive value, RCT renal cell tumour, ccRCC clear cell renal cell carcinoma, pRCC papillary renal cell carcinoma, chRCC chromophobe renal cell carcinoma, RO renal oncocytoma