Establishment of an orthotopic patient-derived xenograft mouse model using uveal melanoma hepatic metastasis

Table 3 Predictive factors for successful engraftment of PDX tumor

	Engraftment of 1st-generation mice (X₁)		p value	Achievement of serial passages to 3rd-generation mice (X₃)		p value		Engraftment of 1st-generation mice (X₁)		p value	Achievement of serial passages to 3rd-generation mice (X₃)		p value
	Success	Failure	p value	Success	Failure	p value		Success	Failure	p value	Success	Failure	p value
Patient gender	n = 12			n = 12			c-myc gain	n = 10			n = 10
Male	5	1	1.00	3	3	1.00	High gain	6	1	1.00	5	2	0.500
Female	5	1	1.00	3	3	1.00	Low gain	2	1	1.00	1	2	0.500
Age	n = 12			n = 12			GNAQ	n = 10			n = 10
≥60	4	2	0.454	2	4	0.567	Positive	4	0	1.00	3	1	0.571
<60	6	0	0.454	4	2	0.567	Negative	5	1	1.00	3	3	0.571
Tumor sample	n = 12			n = 12			GNA11	n = 10			n = 10
Surgery	2	0	1.00	1	1	1.00	Positive	3	0	1.00	2	1	1.00
Biopsy	8	2	1.00	5	5	1.00	Negative	6	1	1.00	4	3	1.00
Pigmentation	n = 12			n = 12			BAP1	n = 10			n = 10
None	4	1	1.00	3	2	1.00	Positive	5	0	1.00	4	1	0.528
Pigments	6	1	1.00	3	4	1.00	Negative	4	1	1.00	2	3	0.528
Ki67 (%)	n = 11			n = 11			SF3B1	n = 10			n = 10
≥10	6	0	0.455	6	0	0.002	Positive	1	1	0.200	0	2	0.133
<10	4	1	0.455	0	5	0.002	Negative	8	0	0.200	6	2	0.133
Monosomy 3	n = 10			n = 10			EIF1AX	n = 10			n = 10
Positive	7	1	0.378	6	2	0.133	Positive	0	0	1.00	0	0	1.00
Negative	1	1	0.378	0	2	0.133	Negative	9	1	1.00	6	4	1.00

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