Skip to main content

Advertisement

Table 3 Predictive factors for successful engraftment of PDX tumor

From: Establishment of an orthotopic patient-derived xenograft mouse model using uveal melanoma hepatic metastasis

  Engraftment of 1st-generation mice (X1) p value Achievement of serial passages to 3rd-generation mice (X3) p value   Engraftment of 1st-generation mice (X1) p value Achievement of serial passages to 3rd-generation mice (X3) p value
Success Failure Success Failure Success Failure Success Failure
Patient gender n = 12    n = 12   c-myc gain n = 10    n = 10  
 Male 5 1 1.00 3 3 1.00  High gain 6 1 1.00 5 2 0.500
 Female 5 1 3 3  Low gain 2 1 1 2
Age n = 12    n = 12   GNAQ n = 10    n = 10  
 ≥60 4 2 0.454 2 4 0.567  Positive 4 0 1.00 3 1 0.571
 <60 6 0 4 2  Negative 5 1 3 3
Tumor sample n = 12    n = 12   GNA11 n = 10    n = 10  
 Surgery 2 0 1.00 1 1 1.00  Positive 3 0 1.00 2 1 1.00
 Biopsy 8 2 5 5  Negative 6 1 4 3
Pigmentation n = 12    n = 12   BAP1 n = 10    n = 10  
 None 4 1 1.00 3 2 1.00  Positive 5 0 1.00 4 1 0.528
 Pigments 6 1 3 4  Negative 4 1 2 3
Ki67 (%) n = 11    n = 11   SF3B1 n = 10    n = 10  
 ≥10 6 0 0.455 6 0 0.002  Positive 1 1 0.200 0 2 0.133
 <10 4 1 0 5  Negative 8 0 6 2
Monosomy 3 n = 10    n = 10   EIF1AX n = 10    n = 10  
 Positive 7 1 0.378 6 2 0.133  Positive 0 0 1.00 0 0 1.00
 Negative 1 1 0 2  Negative 9 1 6 4
  1. Large 4 copies, Small 3 copies or partial 4 copies